Use of heterocyclic compounds for controlling nematodes

ABSTRACT

The present invention relates generally to the use of heterocyclic compounds of the formula (I) 
     
       
         
         
             
             
         
       
     
     for controlling nematodes and to methods useful for controlling nematodes and/or increasing crop yield.

The present invention relates to the use of compounds of formula (I) andcompositions comprising compounds of formula (I) for controllingnematodes in various crops including vegetables, eg tomato, sweetpeppers and cucurbits, potato, corn, soy, cotton, tobacco, coffee,fruits, e.g. citrus fruits, pine apples and bananas, and grapes and tomethods particularly useful for controlling nematodes and/or increasingcrop yield in various crops including vegetables, e.g. tomato, sweetpeppers and cucurbits, potato, pepper, carrots, onions, corn, soy,cotton, tobacco, coffee, sugarcane, fruits, e.g. citrus fruits, pineapples and bananas, and grapes, tree crops—pome fruits, tree crops—stonefruits, tree crops—nuts, and flowers.

Nematodes are tiny, worm-like, multicellular animals adapted to livingin water. The number of nematode species is estimated at half a millionAn important part of the soil fauna, nematodes live in a maze ofinterconnected channels, called pores, that are formed by soilprocesses. They move in the films of water that cling to soil particles.Plant-parasitic nematodes, a majority of which are root feeders, arefound in association with most plants. Some are endoparasitic, livingand feeding within the tissue of the roots, tubers, buds, seeds, leavesetc. Others are ectoparasitic, feeding externally through plant walls. Asingle endoparasitic nematode can kill a plant or reduce itsproductivity. Endoparasitic root feeders include such economicallyimportant pests as the root-knot nematodes (Meloidogyne species), thereniform nematodes (Rotylenchulus species), the cyst nematodes(Heterodera species), and the root-lesion nematodes (Pratylenchusspecies). Direct feeding by nematodes can drastically decrease a plant'suptake of nutrients and water. Nematodes have the greatest impact oncrop productivity when they attack the roots of seedlings immediatelyafter seed germination or transplanting. Nematode feeding also createsopen wounds that provide entry to a wide variety of plant-pathogenicfungi and bacteria. These microbial infections are often moreeconomically damaging than the direct effects of nematode feeding.

Current nematode control focuses essentially on the prevention ofnematode attack on the plant. Once a plant is parasitized it isvirtually impossible to kill the nematode without also destroying theplant. Therefore, it would be advantageous to provide nematode controlcompounds and methods of treating plants to prevent or reduce nematodedamage.

This invention now provides the use of compounds of formula (I)

in which A is A-1 or A-2 or A-3 in which the dotted line represents thebond to the N atom of Q, Q is Q-1 or Q-2 in which the nitrogen isattached to ring A and the arrow in each case represents the bond to theNRCO moiety, R is H or ethyl and W represents a radical from the groupconsisting of W-1 to W-3

in which the dotted line represents the bond to the C═O group,

for controlling nematodes infesting crops selected from the groupconsisting of vegetables, in particular fruity vegetables, e.g. sweetpeppers, melons, egg plants, tomato and cucurbits, potato, pepper,carrots, onions, corn, soy, cotton, tobacco, coffee, sugarcane, fruitse.g. citrus fruits, pine apples and bananas, and grapes, tree crops—pomefruits, tree crops—stone fruits, tree crops—nuts, flowers and/or forincreasing yield.

In one embodiment the invention is directed to the use of a compound offormula (I-1) as listed in Table 1

TABLE 1 (I-1)

Com- pound No. A W R I-1-75 2,6-difluorophenyl (A-1)2-(trifluoromethyl)phenyl (W-1) H I-1-83 2,6-difluorophenyl (A-1)2-iodophenyl (W-2) H I-1- 3,5-difluoro- 2-(trifluoromethyl) H 140pyridin-2-yl (A-2) phenyl (W-1) I-1- 3,5-difluoro- 2-(trifluoromethyl)ethyl 468 pyridin-2-yl (A-2) phenyl (W-1) I-1- 3-cyanopyrazin-2-yl (A-3)2-(trifluoromethyl)phenyl (W-1) H 574

In another embodiment the invention is directed to the use of a compoundof formula (I-2) as listed in Table 2

TABLE 2 (I-2)

Compound No. A W R I-2-35 2,6-difluorophenyl (A-1)2-(trifluoromethyl)phenyl (W-1) H I-2-66 3,5-difluoropyridin-2-yl (A-2)2-(trifluoromethyl)phenyl (W-1) H I-2-71 3,5-difluoropyridin-2-yl (A-2)2-fluoro-6-(trifluormethyl)phenyl (W-3) H

Compounds of formula (I) and their use for controlling nematodes andanimal pests are disclosed with their compound numbers in WO2014/053450. In one biological example the efficacy of selectedcompounds of formula (I) against Meloidogyne incognita in lettuce isdescribed.

The invention relates further to the use of compounds of formula (I) forcontrolling nematodes selected from the group of genera selected fromAphelenchoides spp., Bursaphelenchus spp., Ditylenchus spp., Globoderaspp., Heterodera spp., Longidorus spp., Meloidogyne spp., Pratylenchusspp., Radopholus spp., Trichodorus spp., Tylenchulus spp, Xiphinemaspp., Helicotylenchus spp., Tylenchorhynchus spp., Scutellonema spp.,Paratrichodorus spp., Meloinema spp., Paraphelenchus spp., Aglenchusspp., Belonolaimus spp., Nacobbus spp, Rotylenchulus spp., Rotylenchusspp., Neotylenchus spp., Paraphelenchus spp., Dolichodorus spp.,Hoplolaimus spp., Punctodera spp., Criconemella spp., Quinisulcius spp.,Hemicycliophora spp., Anguina spp., Subanguina spp., Hemicriconemoidesspp., Psilenchus spp., Pseudohalenchus spp., Criconemoides spp.,Cacopaurus spp. infesting crops selected from the group consisting ofvegetables, in particular tomato, peppers, melons, eggplants, andcucurbits, potato, corn, soy, cotton, tobacco, coffee, fruits, inparticular, citrus fruits, pine apples and bananas, and grapes.

The invention relates further to the use of compounds of formula (I) forcontrolling nematodes selected from the group of genera selected fromAphelenchoides spp., Bursaphelenchus spp., Ditylenchus spp., Globoderaspp., Heterodera spp., Longidorus spp., Meloidogyne spp., Pratylenchusspp., Radopholus spp., Trichodorus spp., Tylenchulus spp, Xiphinemaspp., Helicotylenchus spp., Tylenchorhynchus spp., Scutellonema spp.,Paratrichodorus spp., Meloinema spp., Paraphelenchus spp., Aglenchusspp., Belonolaimus spp., Nacobbus spp, Rotylenchulus spp., Rotylenchusspp., Neotylenchus spp., Paraphelenchus spp., Dolichodorus spp.,Hoplolaimus spp., Punctodera spp., Criconemella spp., Quinisulcius spp.,Hemicycliophora spp., Anguina spp., Subanguina spp., Hemicriconemoidesspp., Psilenchus spp., Pseudohalenchus spp., Criconemoides spp.,Cacopaurus spp. infesting crops selected from the group consisting ofvegetables, in particular tomato and cucurbits, potato, pepper, carrots,onions, corn, soy, cotton, tobacco, coffee, sugarcane, fruits, inparticular, citrus fruits, pine apples and bananas, and grapes, treecrops—pome fruits, tree crops—stone fruits, tree crops—nuts, flowersand/or for increasing yield.

The invention relates further to the use of compounds of formula (I) forcontrolling nematode species selected from the group consisting ofAglenchus agricola, Anguina tritici, Aphelenchoides arachidis,Aphelenchoides fragariae, Belonolaimus gracilis, Belonolaimuslongicaudatus, Belonolaimus nortoni, Cacopaurus pestis, Criconemellacurvata, Criconemella onoensis, Criconemella ornata, Criconemellarusium, Criconemella xenoplax (=Mesocriconema xenoplax) and Criconemellaspp. in general, Criconemoides ferniae, Criconemoides onoense,Criconemoides ornatum and Criconemoides spp. in general, Ditylenchusdestructor, Ditylenchus dipsaci, Ditylenchus myceliophagus andDitylenchus spp. in general, Dolichodorus heterocephalus, Globoderapallida (=Heterodera pallida), Globodera rostochiensis, Globoderasolanacearum, Globodera tabacum, Globodera virginiae, Helicotylenchusdigonicus, Helicotylenchus dihystera, Helicotylenchus erythrine,Helicotylenchus multicinctus, Helicotylenchus nannus, Helicotylenchuspseudorobustus and Helicotylenchus spp. in general, Hemicriconemoides,Hemicycliophora arenaria, Hemicycliophora nudata, Hemicycliophoraparvana, Heterodera avenae, Heterodera cruciferae, Heterodera glycines,Heterodera oryzae, Heterodera schachtii, Heterodera zeae and Heteroderaspp. in general, Hoplolaimus aegyptii, Hoplolaimus californicus,Hoplolaimus columbus, Hoplolaimus galeatus, Hoplolaimus indicus,Hoplolaimus magnistylus, Hoplolaimus pararobustus, Longidorus africanus,Longidorus breviannulatus, Longidorus elongatus, Longidoruslaevicapitatus, Longidorus vineacola and Longidorus spp. in general,Meloidogyne acronea, Meloidogyne africana, Meloidogyne arenaria,Meloidogyne arenaria thamesi, Meloidogyne artiella, Meloidogynechitwoodi, Meloidogyne coffeicola, Meloidogyne ethiopica, Meloidogyneexigua, Meloidogyne graminicola, Meloidogyne graminis, Meloidogynehapla, Meloidogyne incognita, Meloidogyne incognita acrita, Meloidogynejavanica, Meloidogyne kikuyensis, Meloidogyne naasi, Meloidogyneparanaensis, Meloidogyne thamesi and Meloidogyne spp. in general,Meloinema spp., Nacobbus aberrans, Neotylenchus vigissi, Paraphelenchuspseudoparietinus, Paratrichodorus allius, Paratrichodorus lobatus,Paratrichodorus minor, Paratrichodorus nanus, Paratrichodorus porosus,Paratrichodorus teres and Paratrichodorus spp. in general, Paratylenchushamatus, Paratylenchus minutus, Paratylenchus projectus andParatylenchus spp. in general, Pratylenchus agilis, Pratylenchus alleni,Pratylenchus andinus, Pratylenchus brachyurus, Pratylenchus cerealis,Pratylenchus coffeae, Pratylenchus crenatus, Pratylenchus delattrei,Pratylenchus giibbicaudatus, Pratylenchus goodeyi, Pratylenchus hamatus,Pratylenchus hexincisus, Pratylenchus loosi, Pratylenchus neglectus,Pratylenchus penetrans, Pratylenchus pratensis, Pratylenchus scribneri,Pratylenchus teres, Pratylenchus thornei, Pratylenchus vulnus,Pratylenchus zeae and Pratylenchus spp. in general, Pseudohalenchusminutus, Psilenchus magnidens, Psilenchus tumidus, Punctoderachalcoensis, Quinisulcius acutus, Radopholus citrophilus, Radopholussimilis, Rotylenchulus borealis, Rotylenchulus parvus, Rotylenchulusreniformis and Rotylenchulus spp. in general, Rotylenchus laurentinus,Rotylenchus macrodoratus, Rotylenchus robustus, Rotylenchus uniformisand Rotylenchus spp. in general, Scutellonema brachyurum, Scutellonemabradys, Scutellonema clathricaudatum and Scutellonema spp. in general,Subanguina radiciola, Tetylenchus nicotianae, Trichodorus cylindricus,Trichodorus minor, Trichodorus primitivus, Trichodorus proximus,Trichodorus similis, Trichodorus sparsus and Trichodorus spp. ingeneral, Tylenchorhynchus agri, Tylenchorhynchus brassicae,Tylenchorhynchus clams, Tylenchorhynchus claytoni, Tylenchorhynchusdigitatus, Tylenchorhynchus ebriensis, Tylenchorhynchus maximus,Tylenchorhynchus nudus, Tylenchorhynchus vulgaris and Tylenchorhynchusspp. in general, Tylenchulus semipenetrans, Xiphinema americanum,Xiphinema brevicolle, Xiphinema dimorphicaudatum, Xiphinema index andXiphinema spp. in general.

An exemplary method of the invention comprises applying compounds offormula (I) of the invention to either soil or a plant (e.g., foliarly)to control nematode damage and/or increase crop yield.

Vegetables are for example broccoli, cauliflower, globe artichokes,Sweet corn (maize), peas, beans, kale, collard greens, spinach, arugula,beet greens, bok choy, chard, choi sum, turnip greens, mustard greens,watercress, garlic chives, gai lan, leeks, brussels sprouts, capers,kohlrabi, celery, rhubarb, cardoon, Chinese celery, lemon grass,asparagus, bamboo shoots, galangal, and ginger, potatoes, Jerusalemartichokes, sweet potatoes, taro, yams soybean sprouts, mung beans,urad, alfalfa, carrots, parsnips, beets, radishes, rutabagas, turnips,burdocks, onions, shallots, garlic, tomatoes, curcurbits (cucumbers,squash, pumpkins, melons, luffas, gourds, watermelons), zucchinis, sweetpeppers, eggplant, tomatillos, christophene, okra, breadfruit andavocado, green beans, lentils, snow peas.

Preferred vegetables are fruity vegetables e.g. tomato, pepper,eggplant, cucurbits e.g. melon, zucchini, cucumber, pumkin, potato,carrots, onions,

Tree crops—stone fruits are e.g. apricots, cherries, almonds andpeaches.

Tree crops—pome fruits are e.g. apples, pears.

Tree crops—nuts are e.g. Beech, Brazil nut, Candlenut, Cashew,Chestnuts, including Chinese Chestnut, Sweet Chestnut, Colocynth,Cucurbita ficifolia, Filbert, Gevuina avellana, Hickory, includingPecan, Shagbark Hickory, Terminalia catappa, Hazelnut, Indian Beech,Kola nut, Macadamia, Malabar chestnut, Pistacia, Mamoncillo, Maya nut,Mongongo, Oak acorns, Ogbono nut, Paradise nut, Pili nut, Walnut, BlackWalnut, Water Caltrop, Mango, Lychee.

In conjunction with the present invention “controlling” denotes apreventive or curative reduction of the nematode infestation incomparison to the untreated crop, more preferably the infestation isessentially repelled, most preferably the infestation is totallysuppressed.

Pathosystems

Compounds of formula (I) are particularly useful in controllingnematodes in coffee belonging to at least one species selected from thegroup of the phytoparasitic nematodes consisting of Pratylenchusbrachyurus, Pratylenchus coffeae, Meloidogyne exigua, Meloidogyneincognita, Meloidogyne coffeicola, Helicotylenchus spp. and alsoconsisting of Meloidogyne paranaensis, Rotylenchus spp., Xiphinema spp.,Tylenchorhynchus spp., Scutellonema spp.

Compounds of formula (I) are particularly useful in controllingnematodes in potato belonging to at least one species selected from thegroup of the phytoparasitic nematodes consisting of Pratylenchusbrachyurus, Pratylenchus pratensis, Pratylenchus scribneri, Pratylenchuspenetrans, Pratylenchus coffeae, Ditylenchus dipsaci and also consistingof Pratylenchus alleni, Pratylenchus andinus, Pratylenchus cerealis,Pratylenchus crenatus, Pratylenchus hexincisus, Pratylenchus loosi,Pratylenchus neglectus, Pratylenchus teres, Pratylenchus thornei,Pratylenchus vulnus, Belonolaimus longicaudatus, Trichodoruscylindricus, Trichodorus primitivus, Trichodorus proximus, Trichodorussimilis, Trichodorus sparsus, Paratrichodorus minor, Paratrichodorusallius, Paratrichodorus nanus, Paratrichodorus teres, Meloidogynearenaria, Meloidogyne hapla, Meloidogyne thamesi, Meloidogyne incognita,Meloidogyne chitwoodi, Meloidogyne javanica, Nacobbus aberrans,Globodera rostochiensis, Globodera pallida, Ditylenchus destructor,Radopholus similis, Rotylenchulus reniformis, Neotylenchus vigissi,Paraphelenchus pseudoparietinus, Aphelenchoides fragariae, Meloinemaspp.

Compounds of formula (I) are particularly useful in controllingnematodes in tomato belonging to at least one species selected from thegroup of the phytoparasitic nematodes consisting of Meloidogynearenaria, Meloidogyne hapla, Meloidogyne javanica, Meloidogyneincognita, Pratylenchus penetrans and also consisting of Pratylenchusbrachyurus, Pratylenchus coffeae, Pratylenchus scribneri, Pratylenchusvulnus, Paratrichodorus minor, Meloidogyne exigua, Nacobbus aberrans,Globodera solanacearum, Dolichodorus heterocephalus, Rotylenchulusreniformis.

Compounds of formula (I) are particularly useful in controllingnematodes in sweet peppers belonging to at least one species selectedfrom the group of the phytoparasitic nematodes consisting ofPratylenchus brachyurus, Pratylenchus pratensis, Pratylenchus scribneri,Pratylenchus penetrans, Pratylenchus coffeae, Ditylenchus dipsaci andalso consisting of Pratylenchus alleni, Pratylenchus andinus,Pratylenchus cerealis, Pratylenchus crenatus, Pratylenchus hexincisus,Pratylenchus loosi, Pratylenchus neglectus, Pratylenchus teres,Pratylenchus thornei, Pratylenchus vulnus, Belonolaimus longicaudatus,Trichodorus cylindricus, Trichodorus primitivus, Trichodorus proximus,Trichodorus similis, Trichodorus sparsus, Paratrichodorus minor,Paratrichodorus allius, Paratrichodorus nanus, Paratrichodorus teres,Meloidogyne arenaria, Meloidogyne hapla, Meloidogyne thamesi,Meloidogyne incognita, Meloidogyne chitwoodi, Meloidogyne javanica,Nacobbus aberrans, Globodera rostochiensis, Globodera pallida,Ditylenchus destructor, Radopholus similis, Rotylenchulus reniformis,Neotylenchus vigissi, Paraphelenchus pseudoparietinus, Aphelenchoidesfragariae, Meloinema spp.

Compounds of formula (I) are particularly useful in controllingnematodes in carrots belonging to at least one species selected from thegroup of the phytoparasitic nematodes consisting of Pratylenchusbrachyurus, Pratylenchus pratensis, Pratylenchus scribneri, Pratylenchuspenetrans, Pratylenchus coffeae, Ditylenchus dipsaci and also consistingof Pratylenchus alleni, Pratylenchus andinus, Pratylenchus cerealis,Pratylenchus crenatus, Pratylenchus hexincisus, Pratylenchus loosi,Pratylenchus neglectus, Pratylenchus teres, Pratylenchus thornei,Pratylenchus vulnus, Belonolaimus longicaudatus, Trichodoruscylindricus, Trichodorus primitivus, Trichodorus proximus, Trichodorussimilis, Trichodorus sparsus, Paratrichodorus minor, Paratrichodorusallius, Paratrichodorus nanus, Paratrichodorus teres, Meloidogynearenaria, Meloidogyne hapla, Meloidogyne thamesi, Meloidogyne incognita,Meloidogyne chitwoodi, Meloidogyne javanica, Nacobbus aberrans,Globodera rostochiensis, Globodera pallida, Ditylenchus destructor,Radopholus similis, Rotylenchulus reniformis, Neotylenchus vigissi,Paraphelenchus pseudoparietinus, Aphelenchoides fragariae, Meloinemaspp.

Compounds of formula (I) are particularly useful in controllingnematodes in onions belonging to at least one species selected from thegroup of the phytoparasitic nematodes consisting of Pratylenchusbrachyurus, Pratylenchus pratensis, Pratylenchus scribneri, Pratylenchuspenetrans, Pratylenchus coffeae, Ditylenchus dipsaci and also consistingof Pratylenchus alleni, Pratylenchus andinus, Pratylenchus cerealis,Pratylenchus crenatus, Pratylenchus hexincisus, Pratylenchus loosi,Pratylenchus neglectus, Pratylenchus teres, Pratylenchus thornei,Pratylenchus vulnus, Belonolaimus longicaudatus, Trichodoruscylindricus, Trichodorus primitivus, Trichodorus proximus, Trichodorussimilis, Trichodorus sparsus, Paratrichodorus minor, Paratrichodorusallius, Paratrichodorus nanus, Paratrichodorus teres, Meloidogynearenaria, Meloidogyne hapla, Meloidogyne thamesi, Meloidogyne incognita,Meloidogyne chitwoodi, Meloidogyne javanica, Nacobbus aberrans,Globodera rostochiensis, Globodera pallida, Ditylenchus destructor,Radopholus similis, Rotylenchulus reniformis, Neotylenchus vigissi,Paraphelenchus pseudoparietinus, Aphelenchoides fragariae, Meloinemaspp.

Compounds of formula (I) are particularly useful in controllingnematodes in cucurbits belonging to at least one species selected fromthe group of the phytoparasitic nematodes consisting of Meloidogynearenaria, Meloidogyne hapla, Meloidogyne javanica, Meloidogyneincognita, Rotylenchulus reniformis and also consisting of Pratylenchusthornei.

Compounds of formula (I) are particularly useful in controllingnematodes in cucurbits belonging to at least one species selected fromthe group of the phytoparasitic nematodes consisting of Meloidogynearenaria, Meloidogyne hapla, Meloidogyne javanica, Rotylenchulusreniformis and also consisting of Pratylenchus thornei.

Compounds of formula (I) are particularly useful in controllingnematodes in cotton belonging to at least one species selected from thegroup of the phytoparasitic nematodes consisting of Belonolaimuslongicaudatus, Meloidogyne incognita, Hoplolaimus columbus, Hoplolaimusgaleatus, Rotylenchulus reniformis.

Compounds of formula (I) are particularly useful in controllingnematodes in corn belonging to at least one species selected from thegroup of the phytoparasitic nematodes, especially consisting ofBelonolaimus longicaudatus, Paratrichodorus minor and also consisting ofPratylenchus brachyurus, Pratylenchus delattrei, Pratylenchushexincisus, Pratylenchus penetrans, Pratylenchus zeae, (Belonolaimusgracilis), Belonolaimus nortoni, Longidorus breviannulatus, Meloidogynearenaria, Meloidogyne arenaria thamesi, Meloidogyne graminis,Meloidogyne incognita, Meloidogyne incognita acrita, Meloidogynejavanica, Meloidogyne naasi, Heterodera avenae, Heterodera oryzae,Heterodera zeae, Punctodera chalcoensis, Ditylenchus dipsaci,Hoplolaimus aegyptii, Hoplolaimus magnistylus, Hoplolaimus galeatus,Hoplolaimus indicus, Helicotylenchus digonicus, Helicotylenchusdihystera, Helicotylenchus pseudorobustus, Xiphinema americanum,Dolichodorus heterocephalus, Criconemella ornata, Criconemella onoensis,Radopholus similis, Rotylenchulus borealis, Rotylenchulus parvus,Tylenchorhynchus agri, Tylenchorhynchus clams, Tylenchorhynchusclaytoni, Tylenchorhynchus maximus, Tylenchorhynchus nudus,Tylenchorhynchus vulgaris, Quinisulcius acutus, Paratylenchus minutus,Hemicycliophora parvana, Aglenchus agricola, Anguina tritici,Aphelenchoides arachidis, Scutellonema brachyumm, Subanguina radiciola.

Compounds of formula (I) are particularly useful in controllingnematodes in soybean belonging to at least one species selected from thegroup of the phytoparasitic nematodes, especially consisting ofPratylenchus brachyurus, Pratylenchus pratensis, Pratylenchus penetrans,Pratylenchus scribneri, Belonolaimus longicaudatus, Heterodera glycines,Hoplolaimus columbus and also consisting of Pratylenchus coffeae,Pratylenchus hexincisus, Pratylenchus neglectus, Pratylenchus crenatus,Pratylenchus alleni, Pratylenchus agilis, Pratylenchus zeae,Pratylenchus vulnus, (Belonolaimus gracilis), Meloidogyne arenaria,Meloidogyne incognita, Meloidogyne javanica, Meloidogyne hapla,Hoplolaimus columbus, Hoplolaimus galeatus, Rotylenchulus reniformis.

Compounds of formula (I) are very particularly useful in controllingnematodes in soybean belonging to at least one species selected from thegroup of the phytoparasitic nematodes, especially consisting ofPratylenchus brachyurus, Pratylenchus pratensis, Pratylenchus penetrans,Pratylenchus scribneri, Belonolaimus longicaudatus, Hoplolaimus columbusand also consisting of Pratylenchus coffeae, Pratylenchus hexincisus,Pratylenchus neglectus, Pratylenchus crenatus, Pratylenchus alleni,Pratylenchus agilis, Pratylenchus zeae, Pratylenchus vulnus,(Belonolaimus gracilis), Meloidogyne arenaria, Meloidogyne incognita,Meloidogyne javanica, Meloidogyne hapla, Hoplolaimus columbus,Hoplolaimus galeatus, Rotylenchulus reniformis.

Compounds of formula (I) are particularly useful in controllingnematodes in tobacco belonging to at least one species selected from thegroup of the phytoparasitic nematodes, especially consisting ofMeloidogyne incognita, Meloidogyne javanica and also consisting ofPratylenchus brachyurus, Pratylenchus pratensis, Pratylenchushexincisus, Pratylenchus penetrans, Pratylenchus neglectus, Pratylenchuscrenatus, Pratylenchus thornei, Pratylenchus vulnus, Pratylenchus zeae,Longidorus elongatu, Paratrichodorus lobatus, Trichodorus spp.,Meloidogyne arenaria, Meloidogyne hapla, Globodera tabacum, Globoderasolanacearum, Globodera virginiae, Ditylenchus dipsaci, Rotylenchusspp., Helicotylenchus spp., Xiphinema americanum, Criconemella spp.,Rotylenchulus reniformis, Tylenchorhynchus claytoni, Paratylenchus spp.,Tetylenchus nicotianae.

Compounds of formula (I) are particularly useful in controllingnematodes in citrus belonging to at least one species selected from thegroup of the phytoparasitic nematodes, especially consisting ofPratylenchus coffeae and also consisting of Pratylenchus brachyurus,Pratylenchus vulnus, Belonolaimus longicaudatus, Paratrichodorus minor,Paratrichodorus porosus, Trichodorus, Meloidogyne incognita, Meloidogyneincognita acrita, Meloidogyne javanica, Rotylenchus macrodoratus,Xiphinema americanum, Xiphinema brevicolle, Xiphinema index,Criconemella spp., Hemicriconemoides, (Radopholus similis), Radopholuscitrophilus, Hemicycliophora arenaria, Hemicycliophora nudata,Tylenchulus semipenetrans.

Compounds of formula (I) are particularly useful in controllingnematodes in banana belonging to at least one species selected from thegroup of the phytoparasitic nematodes, especially consisting ofPratylenchus coffeae, Radopholus similis and also consisting ofPratylenchus giibbicaudatus, Pratylenchus loosi, Meloidogyne spp.,Helicotylenchus multicinctus, Helicotylenchus dihystera, Rotylenchulusspp.

Compounds of formula (I) are particularly useful in controllingnematodes in pine apple belonging to at least one species selected fromthe group of the phytoparasitic nematodes, especially consisting ofPratylenchus zeae, Pratylenchus pratensis, Pratylenchus brachyurus,Pratylenchus goodeyi., Meloidogyne spp., Rotylenchulus reniformis andalso consisting of Longidorus elongatus, Longidorus laevicapitatus,Trichodorus primitivus, Trichodorus minor, Heterodera spp., Ditylenchusmyceliophagus, Hoplolaimus californicus, Hoplolaimus pararobustus,Hoplolaimus indicus, Helicotylenchus dihystera, Helicotylenchus nannus,Helicotylenchus multicinctus, Helicotylenchus erythrine, Xiphinemadimorphicaudatum, Radopholus similis, Tylenchorhynchus digitatus,Tylenchorhynchus ebriensis, Paratylenchus minutus, Scutellonemaclathricaudatum, Scutellonema bradys, Psilenchus tumidus, Psilenchusmagnidens, Pseudohalenchus minutus, Criconemoides ferniae, Criconemoidesonoense, Criconemoides ornatum.

Compounds of formula (I) are particularly useful in controllingnematodes in sugarcane belonging to at least one species selected fromthe group of the phytoparasitic nematodes, especially consisting ofPratylenchus brachyurus, Pratylenchus pratensis, Pratylenchus scribneri,Pratylenchus penetrans, Pratylenchus coffeae, Ditylenchus dipsaci andalso consisting of Pratylenchus alleni, Pratylenchus andinus,Pratylenchus cerealis, Pratylenchus crenatus, Pratylenchus hexincisus,Pratylenchus loosi, Pratylenchus neglectus, Pratylenchus teres,Pratylenchus thornei, Pratylenchus vulnus, Meloidogyne arenaria,Meloidogyne acronea, Meloidogyne artiella, Meloidogyne incognita,Meloidogyne graminicola, Meloidogyne javanica, Meloidogyne thamesi,Meloidogyne hapla, Meloidogyne ethiopica, Meloidogyne africana,Meloidogyne kikuyensis, Helicotylenchus digonicus, Helicotylenchusdihystera, Helicotylenchus pseudorobustus, Rotylenchulus borealis,Rotylenchulus parvus, Rotylenchulus reniformis, Scutellonema brachyurum.

Compounds of formula (I) are particularly useful in controllingnematodes in grapes belonging to at least one species selected from thegroup of the phytoparasitic nematodes, especially consisting ofPratylenchus vulnus, Meloidogyne arenaria, Meloidogyne incognita,Meloidogyne javanica, Xiphinema americanum, Xiphinema index and alsoconsisting of Pratylenchus pratensis, Pratylenchus scribneri,Pratylenchus neglectus, Pratylenchus brachyurus, Pratylenchus thornei,Tylenchulus semipenetrans.

Compounds of formula (I) are particularly useful in controllingnematodes in tree crops—pome fruits, belonging to at least one speciesselected from the group of the phytoparasitic nematodes, especiallyconsisting of Pratylenchus penetrans and also consisting of Pratylenchusvulnus, Longidorus elongatus, Meloidogyne incognita, Meloidogyne hapla.

Compounds of formula (I) are particularly useful in controllingnematodes in tree crops—stone fruits, belonging to at least one speciesselected from the group of the phytoparasitic nematodes, especiallyconsisting of Pratylenchus penetrans, Pratylenchus vulnus, Meloidogynearenaria, Meloidogyne hapla, Meloidogyne javanica, Meloidogyneincognita, Criconemella xenoplax and also consisting of Pratylenchusbrachyurus, Pratylenchus coffeae, Pratylenchus scribneri, Pratylenchuszeae, Belonolaimus longicaudatus, Helicotylenchus dihystera, Xiphinemaamericanum, Criconemella curvata, Tylenchorhynchus claytoni,Paratylenchus hamatus, Paratylenchus projectus, Scutellonema brachyurum,Hoplolaimus galeatus.

Compounds of formula (I) are particularly useful in controllingnematodes in tree crops—nuts, belonging to at least one species selectedfrom the group of the phytoparasitic nematodes, especially consisting ofTrichodorus spp., Criconemella rusium and also consisting ofPratylenchus vulnus, Paratrichodorus spp., Meloidogyne incognita,Helicotylenchus spp., Tylenchorhynchus spp., Cacopaurus pestis.

Definition of Plant Parts

According to the invention all plants and plant parts can be treated. Byplants is meant all plants and plant populations such as desirable andundesirable wild plants, cultivars and plant varieties (whether or notprotectable by plant variety or plant breeder's rights). Cultivars andplant varieties can be plants obtained by conventional propagation andbreeding methods which can be assisted or supplemented by one or morebiotechnological methods such as by use of double haploids, protoplastfusion, random and directed mutagenesis, molecular or genetic markers orby bioengineering and genetic engineering methods. By plant parts ismeant all above ground and below ground parts and organs of plants suchas shoot, leaf, blossom and root, whereby for example leaves, needles,stems, branches, blossoms, fruiting bodies, fruits and seed as well asroots, tubers, corms and rhizomes are listed. Crops and vegetative andgenerative propagating material, for example cuttings, corms, rhizomes,tubers, runners and seeds also belong to plant parts.

As already mentioned above, it is possible to treat all plants and theirparts according to the invention. In one embodiment, wild plant speciesand plant cultivars, or those obtained by conventional biologicalbreeding, such as crossing or protoplast fusion, and parts thereof, aretreated. In a further embodiment, transgenic plants and plant cultivarsobtained by genetic engineering, if appropriate in combination withconventional methods (Genetically Modified Organisms), and parts thereofare treated. The term “parts” or “parts of plants” or “plant parts” hasbeen explained above.

GMOs

Plants of the plant cultivars which are in each case commerciallyavailable or in use can be treated according to the invention. Plantcultivars are to be understood as meaning plants having novel properties(“traits”) which can be obtained by conventional breeding, bymutagenesis or by recombinant DNA techniques. This can be varieties,bio- and genotypes.

The transgenic plants or plant cultivars (i.e. those obtained by geneticengineering) which can be treated according to the invention include allplants which, in the genetic modification, received genetic materialwhich imparted particularly advantageous useful traits to these plants.Examples of such properties are better plant growth, increased toleranceto high or low temperatures, increased tolerance to drought or to wateror soil salt content, increased flowering performance, easierharvesting, accelerated maturation, higher harvest yields, betterquality and/or a higher nutritional value of the harvested products,better storage stability and/or processability of the harvestedproducts. Further and particularly emphasized examples of suchproperties are a better defense of the plants against animal andmicrobial pests, such as against nematodes, insects, mites,phytopathogenic fungi, bacteria and/or viruses, and also increasedtolerance of the plants to certain herbicidal active compounds.Particular emphasis is given to vegetables, in particular tomato andcucurbits, potato, corn, soy, cotton, tobacco, coffee, fruits, inparticular citrus fruits, pine apples and bananas, and grapes.

The method of treatment according to the invention can be used in thetreatment of genetically modified organisms (GMOs), e.g. plants.Genetically modified plants (or transgenic plants) are plants of which aheterologous gene has been stably integrated into genome. The expression“heterologous gene” essentially means a gene which is provided orassembled outside the plant and when introduced in the nuclear,chloroplastic or mitochondrial genome gives the transformed plant new orimproved agronomic or other properties by expressing a protein orpolypeptide of interest or by downregulating or silencing other gene(s)which are present in the plant (using for example, antisense technology,cosuppression technology or RNA interference—RNAi-technology). Aheterologous gene that is located in the genome is also called atransgene. A transgene that is defined by its particular location in theplant genome is called a transformation or transgenic event.

Depending on the plant species or plant cultivars, their location andgrowth conditions (soils, climate, vegetation period, diet), thetreatment according to the invention may also result in superadditive(“synergistic”) effects. Thus, for example, reduced application ratesand/or a widening of the activity spectrum and/or an increase in theactivity of the active compounds and compositions which can be usedaccording to the invention, better plant growth, increased tolerance tohigh or low temperatures, increased tolerance to drought or to water orsoil salt content, increased flowering performance, easier harvesting,accelerated maturation, higher harvest yields, bigger fruits, largerplant height, greener leaf color, earlier flowering, higher qualityand/or a higher nutritional value of the harvested products, highersugar concentration within the fruits, better storage stability and/orprocessability of the harvested products are possible, which exceed theeffects which were actually to be expected.

Plants and plant cultivars which are preferably to be treated accordingto the invention include all plants which have genetic material whichimpart particularly advantageous, useful traits to these plants (whetherobtained by breeding and/or biotechnological means).

Plants and plant cultivars which are also preferably to be treatedaccording to the invention are resistant against one or more bioticstresses, i.e. said plants show a better defense against animal andmicrobial pests, such as against insects, mites, phytopathogenic fungi,bacteria, viruses and/or viroids.

Plants and plant cultivars which may also be treated according to theinvention are those plants which are resistant to one or more abioticstresses. Abiotic stress conditions may include, for example, drought,cold temperature exposure, heat exposure, osmotic stress, flooding,increased soil salinity, increased mineral exposure, ozone exposure,high light exposure, limited availability of nitrogen nutrients, limitedavailability of phosphorus nutrients, shade avoidance.

Plants and plant cultivars which may also be treated according to theinvention, are those plants characterized by enhanced yieldcharacteristics. Increased yield in said plants can be the result of,for example, improved plant physiology, growth and development, such aswater use efficiency, water retention efficiency, improved nitrogen use,enhanced carbon assimilation, improved photosynthesis, increasedgermination efficiency and accelerated maturation. Yield can furthermorebe affected by improved plant architecture (under stress and non-stressconditions), including but not limited to, early flowering, floweringcontrol for hybrid seed production, seedling vigor, plant size,internode number and distance, root growth, seed size, fruit size, podsize, pod or ear number, seed number per pod or ear, seed mass, enhancedseed filling, reduced seed dispersal, reduced pod dehiscence and lodgingresistance. Further yield traits include seed composition, such ascarbohydrate content, protein content, oil content and composition,nutritional value, reduction in anti-nutritional compounds, improvedprocessability and better storage stability.

Plants that may be treated according to the invention are hybrid plantsthat already express the characteristic of heterosis or hybrid vigorwhich results in generally higher yield, vigor, health and resistancetowards biotic and abiotic stresses). Such plants are typically made bycrossing an inbred male-sterile parent line (the female parent) withanother inbred male-fertile parent line (the male parent). Hybrid seedis typically harvested from the male sterile plants and sold to growers.Male sterile plants can sometimes (e.g. in corn) be produced bydetasseling, i.e. the mechanical removal of the male reproductive organs(or males flowers) but, more typically, male sterility is the result ofgenetic determinants in the plant genome. In that case, and especiallywhen seed is the desired product to be harvested from the hybrid plantsit is typically useful to ensure that male fertility in the hybridplants is fully restored. This can be accomplished by ensuring that themale parents have appropriate fertility restorer genes which are capableof restoring the male fertility in hybrid plants that contain thegenetic determinants responsible for male-sterility. Geneticdeterminants for male sterility may be located in the cytoplasm.Examples of cytoplasmic male sterility (CMS) were for instance describedin Brassica species (WO 92/05251, WO 95/09910, WO 98/27806, WO05/002324, WO 06/021972 and U.S. Pat. No. 6,229,072). However, geneticdeterminants for male sterility can also be located in the nucleargenome. Male sterile plants can also be obtained by plant biotechnologymethods such as genetic engineering. A particularly useful means ofobtaining male-sterile plants is described in WO 89/10396 in which, forexample, a ribonuclease such as barnase is selectively expressed in thetapetum cells in the stamens. Fertility can then be restored byexpression in the tapetum cells of a ribonuclease inhibitor such asbarstar (e.g. WO 91/02069).

Plants or plant cultivars (obtained by plant biotechnology methods suchas genetic engineering) which may be treated according to the inventionare herbicide-tolerant plants, i.e. plants made tolerant to one or moregiven herbicides. Such plants can be obtained either by genetictransformation, or by selection of plants containing a mutationimparting such herbicide tolerance.

Herbicide-resistant plants are for example glyphosate-tolerant plants,i.e. plants made tolerant to the herbicide glyphosate or salts thereof.Plants can be made tolerant to glyphosate through different means. Forexample, glyphosate-tolerant plants can be obtained by transforming theplant with a gene encoding the enzyme 5-enolpyruvylshikimate-3-phosphatesynthase (EPSPS). Examples of such EPSPS genes are the AroA gene (mutantCT7) of the bacterium Salmonella typhimurium (Comai et al., 1983,Science 221, 370-371), the CP4 gene of the bacterium Agrobacterium sp.(Barry et al., 1992, Curr. Topics Plant Physiol. 7, 139-145), the genesencoding a Petunia EPSPS (Shah et al., 1986, Science 233, 478-481), aTomato EPSPS (Gasser et al., 1988, J. Biol. Chem. 263, 4280-4289), or anEleusine EPSPS (WO 01/66704). It can also be a mutated EPSPS asdescribed in for example EP 0837944, WO 00/66746, WO 00/66747 orWO02/26995. Glyphosate-tolerant plants can also be obtained byexpressing a gene that encodes a glyphosate oxido-reductase enzyme asdescribed in U.S. Pat. Nos. 5,776,760 and 5,463,175. Glyphosate-tolerantplants can also be obtained by expressing a gene that encodes aglyphosate acetyl transferase enzyme as described in for example WO02/36782, WO 03/092360, WO 05/012515 and WO 07/024782.Glyphosate-tolerant plants can also be obtained by selecting plantscontaining naturally-occurring mutations of the above-mentioned genes,as described in for example WO 01/024615 or WO 03/013226. Plantsexpressing EPSPS genes that confer glyphosate tolerance are described ine.g. U.S. patent application Ser. Nos. 11/517,991, 10/739,610,12/139,408, 12/352,532, 11/312,866, 11/315,678, 12/421,292, 11/400,598,11/651,752, 11/681,285, 11/605,824, 12/468,205, 11/760,570, 11/762,526,11/769,327, 11/769,255, 11/943,801 or 12/362,774. Plants comprisingother genes that confer glyphosate tolerance, such as decarboxylasegenes, are described in e.g. U.S. patent application Ser. Nos.11/588,811, 11/185,342, 12/364,724, 11/185,560 or 12/423,926.

Other herbicide resistant plants are for example plants that are madetolerant to herbicides inhibiting the enzyme glutamine synthase, such asbialaphos, phosphinothricin or glufosinate. Such plants can be obtainedby expressing an enzyme detoxifying the herbicide or a mutant glutaminesynthase enzyme that is resistant to inhibition, e.g. described in U.S.patent application Ser. No. 11/760,602. One such efficient detoxifyingenzyme is an enzyme encoding a phosphinothricin acetyltransferase (suchas the bar or pat protein from Streptomyces species). Plants expressingan exogenous phosphinothricin acetyltransferase are for exampledescribed in U.S. Pat. Nos. 5,561,236; 5,648,477; 5,646,024; 5,273,894;5,637,489; 5,276,268; 5,739,082; 5,908,810 and 7,112,665.

Further herbicide-tolerant plants are also plants that are made tolerantto the herbicides inhibiting the enzyme hydroxyphenylpyruvatedioxygenase(HPPD). Hydroxyphenylpyruvatedioxygenases HPPD is an are enzymes thatcatalyze the reaction in which para-hydroxyphenylpyruvate (HPP) istransformed into homogentisate. Plants tolerant to HPPD-inhibitors canbe transformed with a gene encoding a naturally-occurring resistant HPPDenzyme, or a gene encoding a mutated or chimeric HPPD enzyme asdescribed in WO 96/38567, WO 99/24585, and WO 99/24586, WO 2009/144079,WO 2002/046387, or U.S. Pat. No. 6,768,044. Tolerance to HPPD-inhibitorscan also be obtained by transforming plants with genes encoding certainenzymes enabling the formation of homogentisate despite the inhibitionof the native HPPD enzyme by the HPPD-inhibitor. Such plants and genesare described in WO 99/34008 and WO 02/36787. Tolerance of plants toHPPD inhibitors can also be improved by transforming plants with a geneencoding an enzyme having prephenate deshydrogenase (PDH) activity inaddition to a gene encoding an HPPD-tolerant enzyme, as described in WO2004/024928. Further, plants can be made more tolerant to HPPD-inhibitorherbicides by adding into their genome a gene encoding an enzyme capableof metabolizing or degrading HPPD inhibitors, such as the CYP450 enzymesshown in WO 2007/103567 and WO 2008/150473.

Still further herbicide resistant plants are plants that are madetolerant to acetolactate synthase (ALS) inhibitors. Known ALS-inhibitorsinclude, for example, sulfonylurea, imidazolinone, triazolopyrimidines,pryimidinyoxy(thio)benzoates, and/or sulfonylaminocarbonyltriazolinoneherbicides. Different mutations in the ALS enzyme (also known asacetohydroxyacid synthase, AHAS) are known to confer tolerance todifferent herbicides and groups of herbicides, as described for examplein Tranel and Wright (2002, Weed Science 50:700-712), but also, in U.S.Pat. Nos. 5,605,011, 5,378,824, 5,141,870, and 5,013,659. The productionof sulfonylurea-tolerant plants and imidazolinone-tolerant plants isdescribed in U.S. Pat. Nos. 5,605,011; 5,013,659; 5,141,870; 5,767,361;5,731,180; 5,304,732; 4,761,373; 5,331,107; 5,928,937; and 5,378,824;and international publication WO 96/33270. Other imidazolinone-tolerantplants are also described in for example WO 2004/040012, WO 2004/106529,WO 2005/020673, WO 2005/093093, WO 2006/007373, WO 2006/015376, WO2006/024351, and WO 2006/060634. Further sulfonylurea- andimidazolinone-tolerant plants are also described in for example WO07/024782 and U.S. Patent Application No. 61/288,958.

Other plants tolerant to imidazolinone and/or sulfonylurea can beobtained by induced mutagenesis, selection in cell cultures in thepresence of the herbicide or mutation breeding as described for examplefor soybeans in U.S. Pat. No. 5,084,082, for rice in WO 97/41218, forsugar beet in U.S. Pat. No. 5,773,702 and WO 99/057965, or for sunflowerin WO 01/065922.

Plants or plant cultivars (obtained by plant biotechnology methods suchas genetic engineering) which may also be treated according to theinvention are insect-resistant transgenic plants, i.e. plants maderesistant to attack by certain target insects. Such plants can beobtained by genetic transformation, or by selection of plants containinga mutation imparting such insect resistance.

An “insect-resistant transgenic plant”, as used herein, includes anyplant containing at least one transgene comprising a coding sequenceencoding:

1) an insecticidal crystal protein from Bacillus thuringiensis or aninsecticidal portion thereof, such as the insecticidal crystal proteinslisted by Crickmore et al. (1998, Microbiology and Molecular BiologyReviews, 62: 807-813), updated by Crickmore et al. (2005) at theBacillus thuringiensis toxin nomenclature, online at:

http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/), orinsecticidal portions thereof, e.g., proteins of the Cry protein classesCry1Ab, Cry1Ac, Cry1B, Cry1C, Cry1D, Cry1F, Cry2Ab, Cry3Aa, or Cry3Bb orinsecticidal portions thereof (e.g. EP 1999141 and WO 2007/107302), orsuch proteins encoded by synthetic genes as e.g. described in and U.S.patent application Ser. No. 12/249,016; or

2) a crystal protein from Bacillus thuringiensis or a portion thereofwhich is insecticidal in the presence of a second other crystal proteinfrom Bacillus thuringiensis or a portion thereof, such as the binarytoxin made up of the Cry34 and Cry35 crystal proteins (Moellenbeck etal. 2001, Nat. Biotechnol. 19: 668-72; Schnepf et al. 2006, AppliedEnvironm. Microbiol. 71, 1765-1774) or the binary toxin made up of theCry1A or Cry1F proteins and the Cry2Aa or Cry2Ab or Cry2Ae proteins(U.S. patent application Ser. No. 12/214,022 and EP 08010791.5); or

3) a hybrid insecticidal protein comprising parts of differentinsecticidal crystal proteins from Bacillus thuringiensis, such as ahybrid of the proteins of 1) above or a hybrid of the proteins of 2)above, e.g., the Cry1A.105 protein produced by corn event MON89034 (WO2007/027777); or

4) a protein of any one of 1) to 3) above wherein some, particularly 1to 10, amino acids have been replaced by another amino acid to obtain ahigher insecticidal activity to a target insect species, and/or toexpand the range of target insect species affected, and/or because ofchanges introduced into the encoding DNA during cloning ortransformation, such as the Cry3Bb1 protein in corn events MON863 orMON88017, or the Cry3A protein in corn event MIR604; or

5) an insecticidal secreted protein from Bacillus thuringiensis orBacillus cereus, or an insecticidal portion thereof, such as thevegetative insecticidal (VIP) proteins listed at:

http://www.lifesci.sussex.ac.uk/home/Neil_Crickmore/Bt/vip.html, e.g.,proteins from the VIP3Aa protein class; or

6) a secreted protein from Bacillus thuringiensis or Bacillus cereuswhich is insecticidal in the presence of a second secreted protein fromBacillus thuringiensis or B. cereus, such as the binary toxin made up ofthe VIP1A and VIP2A proteins (WO 94/21795); or

7) a hybrid insecticidal protein comprising parts from differentsecreted proteins from Bacillus thuringiensis or Bacillus cereus, suchas a hybrid of the proteins in 1) above or a hybrid of the proteins in2) above; or

8) a protein of any one of 5) to 7) above wherein some, particularly 1to 10, amino acids have been replaced by another amino acid to obtain ahigher insecticidal activity to a target insect species, and/or toexpand the range of target insect species affected, and/or because ofchanges introduced into the encoding DNA during cloning ortransformation (while still encoding an insecticidal protein), such asthe VIP3Aa protein in cotton event COT102; or

9) a secreted protein from Bacillus thuringiensis or Bacillus cereuswhich is insecticidal in the presence of a crystal protein from Bacillusthuringiensis, such as the binary toxin made up of VIP3 and Cry1A orCry1F (U.S. Patent Appl. No. 61/126,083 and 61/195019), or the binarytoxin made up of the VIP3 protein and the Cry2Aa or Cry2Ab or Cry2Aeproteins (U.S. patent application Ser. No. 12/214,022 and EP08010791.5).

10) a protein of 9) above wherein some, particularly 1 to 10, aminoacids have been replaced by another amino acid to obtain a higherinsecticidal activity to a target insect species, and/or to expand therange of target insect species affected, and/or because of changesintroduced into the encoding DNA during cloning or transformation (whilestill encoding an insecticidal protein)

Of course, an insect-resistant transgenic plant, as used herein, alsoincludes any plant comprising a combination of genes encoding theproteins of any one of the above classes 1 to 10. In one embodiment, aninsect-resistant plant contains more than one transgene encoding aprotein of any one of the above classes 1 to 10, to expand the range oftarget insect species affected when using different proteins directed atdifferent target insect species, or to delay insect resistancedevelopment to the plants by using different proteins insecticidal tothe same target insect species but having a different mode of action,such as binding to different receptor binding sites in the insect.

An “insect-resistant transgenic plant”, as used herein, further includesany plant containing at least one transgene comprising a sequenceproducing upon expression a double-stranded RNA which upon ingestion bya plant insect pest inhibits the growth of this insect pest, asdescribed e.g. in WO 2007/080126, WO 2006/129204, WO 2007/074405, WO2007/080127 and WO 2007/035650.

Plants or plant cultivars (obtained by plant biotechnology methods suchas genetic engineering) which may also be treated according to theinvention are tolerant to abiotic stresses. Such plants can be obtainedby genetic transformation, or by selection of plants containing amutation imparting such stress resistance. Particularly useful stresstolerance plants include:

1) plants which contain a transgene capable of reducing the expressionand/or the activity of poly(ADP-ribose) polymerase (PARP) gene in theplant cells or plants as described in WO 00/04173, WO/2006/045633, EP04077984.5, or EP 06009836.5.

2) plants which contain a stress tolerance enhancing transgene capableof reducing the expression and/or the activity of the PARG encodinggenes of the plants or plants cells, as described e.g. in WO2004/090140.

3) plants which contain a stress tolerance enhancing transgene codingfor a plant-functional enzyme of the nicotineamide adenine dinucleotidesalvage synthesis pathway including nicotinamidase, nicotinatephosphoribosyltransferase, nicotinic acid mononucleotide adenyltransferase, nicotinamide adenine dinucleotide synthetase or nicotineamide phosphorybosyltransferase as described e.g. in EP 04077624.7, WO2006/133827, PCT/EP07/002433, EP 1999263, or WO 2007/107326.

Plants or plant cultivars (obtained by plant biotechnology methods suchas genetic engineering) which may also be treated according to theinvention show altered quantity, quality and/or storage-stability of theharvested product and/or altered properties of specific ingredients ofthe harvested product such as:

1) transgenic plants which synthesize a modified starch, which in itsphysical-chemical characteristics, in particular the amylose content orthe amylose/amylopectin ratio, the degree of branching, the averagechain length, the side chain distribution, the viscosity behaviour, thegelling strength, the starch grain size and/or the starch grainmorphology, is changed in comparison with the synthesised starch in wildtype plant cells or plants, so that this is better suited for specialapplications. Said transgenic plants synthesizing a modified starch aredisclosed, for example, in EP 0571427, WO 95/04826, EP 0719338, WO96/15248, WO 96/19581, WO 96/27674, WO 97/11188, WO 97/26362, WO97/32985, WO 97/42328, WO 97/44472, WO 97/45545, WO 98/27212, WO98/40503, WO99/58688, WO 99/58690, WO 99/58654, WO 00/08184, WO00/08185, WO 00/08175, WO 00/28052, WO 00/77229, WO 01/12782, WO01/12826, WO 02/101059, WO 03/071860, WO 2004/056999, WO 2005/030942, WO2005/030941, WO 2005/095632, WO 2005/095617, WO 2005/095619, WO2005/095618, WO 2005/123927, WO 2006/018319, WO 2006/103107, WO2006/108702, WO 2007/009823, WO 00/22140, WO 2006/063862, WO2006/072603, WO 02/034923, EP 06090134.5, EP 06090228.5, EP 06090227.7,EP 07090007.1, EP 07090009.7, WO 01/14569, WO 02/79410, WO 03/33540, WO2004/078983, WO 01/19975, WO 95/26407, WO 96/34968, WO 98/20145, WO99/12950, WO 99/66050, WO 99/53072, U.S. Pat. No. 6,734,341, WO00/11192, WO 98/22604, WO 98/32326, WO 01/98509, WO 01/98509, WO2005/002359, U.S. Pat. No. 5,824,790, U.S. Pat. No. 6,013,861, WO94/04693, WO 94/09144, WO 94/11520, WO 95/35026, WO 97/20936

2) transgenic plants which synthesize non starch carbohydrate polymersor which synthesize non starch carbohydrate polymers with alteredproperties in comparison to wild type plants without geneticmodification. Examples are plants producing polyfructose, especially ofthe inulin and levan-type, as disclosed in EP 0663956, WO 96/01904, WO96/21023, WO 98/39460, and WO 99/24593, plants producingalpha-1,4-glucans as disclosed in WO 95/31553, US 2002031826, U.S. Pat.No. 6,284,479, U.S. Pat. No. 5,712,107, WO 97/47806, WO 97/47807, WO97/47808 and WO 00/14249, plants producing alpha-1,6 branchedalpha-1,4-glucans, as disclosed in WO 00/73422, plants producingalternan, as disclosed in e.g. WO 00/47727, WO 00/73422, EP 06077301.7,U.S. Pat. No. 5,908,975 and EP 0728213, 3) transgenic plants whichproduce hyaluronan, as for example disclosed in WO 2006/032538, WO2007/039314, WO 2007/039315, WO 2007/039316, JP 2006304779, and WO2005/012529.

4) transgenic plants or hybrid plants, such as onions withcharacteristics such as ‘high soluble solids content’, low pungency′(LP) and/or ‘long storage’ (LS), as described in U.S. patent applicationSer. No. 12/020,360 and 61/054,026.

Plants or plant cultivars (that can be obtained by plant biotechnologymethods such as genetic engineering) which may also be treated accordingto the invention are plants, such as cotton plants, with altered fibercharacteristics. Such plants can be obtained by genetic transformation,or by selection of plants contain a mutation imparting such alteredfiber characteristics and include:

a) Plants, such as cotton plants, containing an altered form ofcellulose synthase genes as described in WO 98/00549

b) Plants, such as cotton plants, containing an altered form of rsw2 orrsw3 homologous nucleic acids as described in WO 2004/053219

c) Plants, such as cotton plants, with increased expression of sucrosephosphate synthase as described in WO 01/17333

d) Plants, such as cotton plants, with increased expression of sucrosesynthase as described in WO 02/45485

e) Plants, such as cotton plants, wherein the timing of theplasmodesmatal gating at the basis of the fiber cell is altered, e.g.through downregulation of fiber-selective β-1,3-glucanase as describedin WO 2005/017157, or as described in EP 08075514.3 or U.S. Patent Appl.No. 61/128,938

f) Plants, such as cotton plants, having fibers with altered reactivity,e.g. through the expression of N-acetylglucosaminetransferase geneincluding nodC and chitin synthase genes as described in WO 2006/136351

Plants or plant cultivars (that can be obtained by plant biotechnologymethods such as genetic engineering) which may also be treated accordingto the invention are plants, such as oilseed rape or related Brassicaplants, with altered oil profile characteristics. Such plants can beobtained by genetic transformation, or by selection of plants contain amutation imparting such altered oil profile characteristics and include:

a) Plants, such as oilseed rape plants, producing oil having a higholeic acid content as described e.g. in U.S. Pat. No. 5,969,169, U.S.Pat. No. 5,840,946 or U.S. Pat. No. 6,323,392 or U.S. Pat. No. 6,063,947

b) Plants such as oilseed rape plants, producing oil having a lowlinolenic acid content as described in U.S. Pat. No. 6,270,828, U.S.Pat. No. 6,169,190, or U.S. Pat. No. 5,965,755

c) Plant such as oilseed rape plants, producing oil having a low levelof saturated fatty acids as described e.g. in U.S. Pat. No. 5,434,283 orU.S. patent application Ser. No. 12/668,303

Plants or plant cultivars (that can be obtained by plant biotechnologymethods such as genetic engineering) which may also be treated accordingto the invention are plants, such as potatoes which are virus-resistant,e.g. against potato virus Y (event SY230 and SY233 from Tecnoplant,Argentina), which are disease resistant, e.g. against potato late blight(e.g. RB gene), which show a reduction in cold-induced sweetening(carrying the Nt-Inhh, IIR-INV gene) or which possess a dwarf phenotype(Gene A-20 oxidase).

Particularly useful transgenic plants which may be treated according tothe invention are plants containing transformation events, orcombination of transformation events, that are the subject of petitionsfor non-regulated status, in the United States of America, to the Animaland Plant Health Inspection Service (APHIS) of the United StatesDepartment of Agriculture (USDA) whether such petitions are granted orare still pending. At any time this information is readily availablefrom APHIS (4700 River Road Riverdale, Md. 20737, USA), for instance onits internet site (URL http://www.aphis.usda.gov/brs/not_reg.html). Onthe filing date of this application the petitions for nonregulatedstatus that were pending with APHIS or granted by APHIS were thoselisted in table B which contains the following information:

-   -   Petition: the identification number of the petition. Technical        descriptions of the transformation events can be found in the        individual petition documents which are obtainable from APHIS,        for example on the APHIS website, by reference to this petition        number. These descriptions are herein incorporated by reference.    -   Extension of Petition: reference to a previous petition for        which an extension is requested.    -   Institution: the name of the entity submitting the petition.    -   Regulated article: the plant species concerned.    -   Transgenic phenotype: the trait conferred to the plants by the        transformation event.    -   Transformation event or line: the name of the event or events        (sometimes also designated as lines or lines) for which        nonregulated status is requested.    -   APHIS documents: various documents published by APHIS in        relation to the Petition and which can be requested with APHIS.

Additional particularly useful plants containing single transformationevents or combinations of transformation events are listed for examplein the databases from various national or regional regulatory agencies(see for example http://gmoinfo.jrc.it/gmp_browse.aspx andhttp://www.agbios.com/dbase.php).

The present invention relates also to the use of compounds of formula(I) for controlling nematodes in plants containing transformationevents, or a combination of transformation events, and that are listedfor example in the databases for various national or regional regulatoryagencies including Event 1143-14A (cotton, insect control, notdeposited, described in WO2006/128569); Event 1143-51B (cotton, insectcontrol, not deposited, described in WO2006/128570); Event 1445 (cotton,herbicide tolerance, not deposited, described in US2002120964 orWO2002/034946); Event 17053 (rice, herbicide tolerance, deposited asPTA-9843, described in WO2010/117737); Event 17314 (rice, herbicidetolerance, deposited as PTA-9844, described in WO2010/117735); Event281-24-236 (cotton, insect control—herbicide tolerance, deposited asPTA-6233, described in WO2005/103266 or US2005216969); Event 3006-210-23(cotton, insect control—herbicide tolerance, deposited as PTA-6233,described in US2007143876 or WO2005/103266); Event 3272 (corn, qualitytrait, deposited as PTA-9972, described in WO2006098952 orUS2006230473); Event 40416 (corn, insect control—herbicide tolerance,deposited as ATCC PTA-11508, described in WO2011/075593); Event 43A47(corn, insect control—herbicide tolerance, deposited as ATCC PTA-11509,described in WO2011/075595); Event 5307 (corn, insect control, depositedas ATCC PTA-9561, described in WO2010/077816); Event ASR-368 (bentgrass, herbicide tolerance, deposited as ATCC PTA-4816, described inUS2006162007 or WO2004053062); Event B16 (corn, herbicide tolerance, notdeposited, described in US2003126634); Event BPS-CV127-9 (soybean,herbicide tolerance, deposited as NCIMB No. 41603, described inWO2010/080829); Event CE43-67B (cotton, insect control, deposited as DSMACC2724, described in US2009217423 or WO2006/128573); Event CE44-69D(cotton, insect control, not deposited, described in US20100024077);Event CE44-69D (cotton, insect control, not deposited, described inWO2006/128571); Event CE46-02A (cotton, insect control, not deposited,described in WO2006/128572); Event COT102 (cotton, insect control, notdeposited, described in US2006130175 or WO2004039986); Event COT202(cotton, insect control, not deposited, described in US2007067868 orWO2005054479); Event COT203 (cotton, insect control, not deposited,described in WO2005/054480); Event DAS40278 (corn, herbicide tolerance,deposited as ATCC PTA-10244, described in WO2011/022469); EventDAS-59122-7 (corn, insect control—herbicide tolerance, deposited as ATCCPTA 11384, described in US2006070139); Event DAS-59132 (corn, insectcontrol—herbicide tolerance, not deposited, described in WO2009/100188);Event DAS68416 (soybean, herbicide tolerance, deposited as ATCCPTA-10442, described in WO2011/066384 or WO2011/066360); EventDP-098140-6 (corn, herbicide tolerance, deposited as ATCC PTA-8296,described in US2009137395 or WO2008/112019); Event DP-305423-1 (soybean,quality trait, not deposited, described in US2008312082 orWO2008/054747); Event DP-32138-1 (corn, hybridization system, depositedas ATCC PTA-9158, described in US20090210970 or WO2009/103049); EventDP-356043-5 (soybean, herbicide tolerance, deposited as ATCC PTA-8287,described in US20100184079 or WO2008/002872); Event EE-1 (brinjal,insect control, not deposited, described in WO2007/091277); Event FI117(corn, herbicide tolerance, deposited as ATCC 209031, described inUS2006059581 or WO1998/044140); Event GA21 (corn, herbicide tolerance,deposited as ATCC 209033, described in US2005086719 or WO1998/044140);Event GG25 (corn, herbicide tolerance, deposited as ATCC 209032,described in US2005188434 or WO1998/044140); Event GHB119 (cotton,insect control—herbicide tolerance, deposited as ATCC PTA-8398,described in WO2008/151780); Event GHB614 (cotton, herbicide tolerance,deposited as ATCC PTA-6878, described in US2010050282 or WO2007/017186);Event GM (corn, herbicide tolerance, deposited as ATCC 209030, describedin US2005188434 or WO1998/044140); Event GM RZ13 (sugar beet, virusresistance, deposited as NCIMB-41601, described in WO2010/076212); EventH7-1 (sugar beet, herbicide tolerance, deposited as NCIMB 41158 or NCIMB41159, described in US2004172669 or WO2004/074492); Event JOPLIN1(wheat, disease tolerance, not deposited, described in US2008064032);Event LL27 (soybean, herbicide tolerance, deposited as NCIMB41658,described in WO2006/108674 or US2008320616); Event LL55 (soybean,herbicide tolerance, deposited as NCIMB 41660, described inWO2006/108675 or US2008196127); Event LLcotton25 (cotton, herbicidetolerance, deposited as ATCC PTA-3343, described in WO2003013224 orUS2003097687); Event LLRICE06 (rice, herbicide tolerance, deposited asATCC-23352, described in U.S. Pat. No. 6,468,747 or WO2000/026345);Event LLRICE601 (rice, herbicide tolerance, deposited as ATCC PTA-2600,described in US20082289060 or WO2000/026356); Event LY038 (corn, qualitytrait, deposited as ATCC PTA-5623, described in US2007028322 orWO2005061720); Event MIR162 (corn, insect control, deposited asPTA-8166, described in US2009300784 or WO2007/142840); Event MIR604(corn, insect control, not deposited, described in US2008167456 orWO2005103301); Event MON15985 (cotton, insect control, deposited as ATCCPTA-2516, described in US2004-250317 or WO2002/100163); Event MON810(corn, insect control, not deposited, described in US2002102582); EventMON863 (corn, insect control, deposited as ATCC PTA-2605, described inWO2004/011601 or US2006095986); Event MON87427 (corn, pollinationcontrol, deposited as ATCC PTA-7899, described in WO2011/062904); EventMON87460 (corn, stress tolerance, deposited as ATCC PTA-8910, describedin WO2009/111263 or US20110138504); Event MON87701 (soybean, insectcontrol, deposited as ATCC PTA-8194, described in US2009130071 orWO2009/064652); Event MON87705 (soybean, quality trait—herbicidetolerance, deposited as ATCC PTA-9241, described in US20100080887 orWO2010/037016); Event MON87708 (soybean, herbicide tolerance, depositedas ATCC PTA9670, described in WO2011/034704); Event MON87754 (soybean,quality trait, deposited as ATCC PTA-9385, described in WO2010/024976);Event MON87769 (soybean, quality trait, deposited as ATCC PTA-8911,described in US20110067141 or WO2009/102873); Event MON88017 (corn,insect control—herbicide tolerance, deposited as ATCC PTA-5582,described in US2008028482 or WO2005/059103); Event MON88913 (cotton,herbicide tolerance, deposited as ATCC PTA-4854, described inWO2004/072235 or US2006059590); Event MON89034 (corn, insect control,deposited as ATCC PTA-7455, described in WO2007/140256 or US2008260932);Event MON89788 (soybean, herbicide tolerance, deposited as ATCCPTA-6708, described in US2006282915 or WO2006/130436); Event MS11(oilseed rape, pollination control—herbicide tolerance, deposited asATCC PTA-850 or PTA-2485, described in WO2001/031042); Event MS8(oilseed rape, pollination control—herbicide tolerance, deposited asATCC PTA-730, described in WO2001/041558 or US2003188347); Event NK603(corn, herbicide tolerance, deposited as ATCC PTA-2478, described inUS2007-292854); Event PE-7 (rice, insect control, not deposited,described in WO2008/114282); Event RF3 (oilseed rape, pollinationcontrol—herbicide tolerance, deposited as ATCC PTA-730, described inWO2001/041558 or US2003188347); Event RT73 (oilseed rape, herbicidetolerance, not deposited, described in WO2002/036831 or US2008070260);Event T227-1 (sugar beet, herbicide tolerance, not deposited, describedin WO2002/44407 or US2009265817); Event T25 (corn, herbicide tolerance,not deposited, described in US2001029014 or WO2001/051654); EventT304-40 (cotton, insect control—herbicide tolerance, deposited as ATCCPTA-8171, described in US2010077501 or WO2008/122406); Event T342-142(cotton, insect control, not deposited, described in WO2006/128568);Event TC1507 (corn, insect control—herbicide tolerance, not deposited,described in US2005039226 or WO2004/099447); Event VIP1034 (corn, insectcontrol—herbicide tolerance, deposited as ATCC PTA-3925., described inWO2003/052073), Event 32316 (corn, insect control-herbicide tolerance,deposited as PTA-11507, described in WO2011/084632), Event 4114 (corn,insect control-herbicide tolerance, deposited as PTA-11506, described inWO2011/084621).

The present invention relates also to the use of compounds of formula(I) for controlling nematodes in plants carrying the one or more of theevents listed in Table A below:

TABLE A Event Company Description A-1 ASR368 Scotts Seeds Glyphosatetolerance derived by inserting a modified5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) encoding gene fromAgrobacterium tumefaciens, parent line B99061 A-2 GM RZ13 Beet NecroticYellow Vein Virus (BNYVV) resistance A-3 H7-1 Monsanto CompanyGlyphosate herbicide tolerant sugar beet produced by inserting a geneencoding the enzyme 5- enolypyruvylshikimate-3-phosphate synthase(EPSPS) from the CP4 strain of Agrobacterium tumefaciens,; WO2004-074492 A-4 T120-7 Bayer CropScience Introduction of thePPT-acetyltransferase (PAT) (Aventis encoding gene from StreptomycesCropScience(AgrEvo)) viridochromogenes, an aerobic soil bacteria. PPTnormally acts to inhibit glutamine synthetase, causing a fatalaccumulation of ammonia. Acetylated PPT is inactive. A-5 GTSB77 NovartisSeeds; Monsanto Glyphosate herbicide tolerant sugar beet producedCompany by inserting a gene encoding the enzyme 5-enolypyruvylshikimate-3-phosphate synthase (EPSPS) from the CP4 strainof Agrobacterium tumefaciens. A-6 T227-1 Glyphosate tolerance; US2004-117870 A-7 23-18-17, 23-198 Monsanto Company High laurate (12:0)and myristate (14:0) canola (formerly Calgene) produced by inserting athioesterase encoding gene from the California bay laurel (Umbellulariacalifornica). A-8 45A37, 46A40 Pioneer Hi-Bred High oleic acid and lowlinolenic acid canola International Inc. produced through a combinationof chemical mutagenesis to select for a fatty acid desaturase mutantwith elevated oleic acid, and traditional back-crossing to introduce thelow linolenic acid trait. A-9 46A12, 46A16 Pioneer Hi-Bred Combinationof chemical mutagenesis, to achieve International Inc. the high oleicacid trait, and traditional breeding with registered canola varieties.A- GT200 Monsanto Company Glyphosate herbicide tolerant canola producedby 10 inserting genes encoding the enzymes 5-enolypyruvylshikimate-3-phosphate synthase (EPSPS) from the CP4 strainof Agrobacterium tumefaciens and glyphosate oxidase from Ochrobactrumanthropi. A- GT73, RT73 Monsanto Company Glyphosate herbicide tolerantcanola produced by 11 inserting genes encoding the enzymes 5-enolypyruvylshikimate-3-phosphate synthase (EPSPS) from the CP4 strainof Agrobacterium tumefaciens and glyphosate oxidase from Ochrobactrumanthropi. A- HCN10 Aventis CropScience Introduction of thePPT-acetyltransferase (PAT) 12 encoding gene from Streptomycesviridochromogenes, an aerobic soil bacteria. PPT normally acts toinhibit glutamine synthetase, causing a fatal accumulation of ammonia.Acetylated PPT is inactive. A- HCN92 Bayer CropScience Introduction ofthe PPT-acetyltransferase (PAT) 13 (Aventis encoding gene fromStreptomyces CropScience(AgrEvo)) viridochromogenes, an aerobic soilbacteria. PPT normally acts to inhibit glutamine synthetase, causing afatal accumulation of ammonia. Acetylated PPT is inactive. A- MS1, RF1=>PGS1 Aventis CropScience Male-sterility, fertility restoration,pollination 14 (formerly Plant Genetic control system displayingglufosinate herbicide Systems) tolerance. MS lines contained the barnasegene from Bacillus amyloliquefaciens, RF lines contained the barstargene from the same bacteria, and both lines contained thephosphinothricin N- acetyltransferase (PAT) encoding gene fromStreptomyces hygroscopicus. A- MS1, RF2 =>PGS2 Aventis CropScienceMale-sterility, fertility restoration, pollination 15 (formerly PlantGenetic control system displaying glufosinate herbicide Systems)tolerance. MS lines contained the barnase gene from Bacillusamyloliquefaciens, RF lines contained the barstar gene from the samebacteria, and both lines contained the phosphinothricin N-acetyltransferase (PAT) encoding gene from Streptomyces hygroscopicus.A- MS8×RF3 Bayer CropScience Male-sterility, fertility restoration,pollination 16 (Aventis control system displaying glufosinate herbicideCropScience(AgrEvo)) tolerance. MS lines contained the barnase gene fromBacillus amyloliquefaciens, RF lines contained the barstar gene from thesame bacteria, and both lines contained the phosphinothricin N-acetyltransferase (PAT) encoding gene from Streptomyces hygroscopicus.A- MS-B2 Male sterility; WO 01/31042 17 A- MS-BN1/RF-BN1 Malesterility/restoration; WO 01/41558 18 A- NS738, NS1471, Pioneer Hi-BredSelection of somaclonal variants with altered 19 NS1473 InternationalInc. acetolactate synthase (ALS) enzymes, following chemicalmutagenesis. Two lines (P1, P2) were initially selected withmodifications at different unlinked loci. NS738 contains the P2 mutationonly. A- OXY-235 Aventis CropScience Tolerance to the herbicidesbromoxynil and 20 (formerly Rhone Poulenc ioxynil by incorporation ofthe nitrilase gene from Inc.) Klebsiella pneumoniae. A- PHY14, PHY35Aventis CropScience Male sterility was via insertion of the barnase 21(formerly Plant Genetic ribonuclease gene from Bacillus Systems)amyloliquefaciens; fertility restoration by insertion of the barstarRNase inhibitor; PPT resistance was via PPT-acetyltransferase (PAT) fromStreptomyces hygroscopicus. A- PHY36 Aventis CropScience Male sterilitywas via insertion of the barnase 22 (formerly Plant Genetic ribonucleasegene from Bacillus Systems) amyloliquefaciens; fertility restoration byinsertion of the barstar RNase inhibitor; PPT resistance was viaPPT-acetyltransferase (PAT) from Streptomyces hygroscopicus. A- RT73Glyphosate resistance; WO 02/36831 23 A- T45 (HCN28) Bayer CropScienceIntroduction of the PPT-acetyltransferase (PAT) 24 (Aventis encodinggene from Streptomyces CropScience(AgrEvo)) viridochromogenes, anaerobic soil bacteria. PPT normally acts to inhibit glutaminesynthetase, causing a fatal accumulation of ammonia. Acetylated PPT isinactive. A- HCR-1 Bayer CropScience Introduction of the glufosinateammonium 25 (Aventis herbicide tolerance trait from transgenic B. napusCropScience(AgrEvo)) line T45. This trait is mediated by thephosphinothricin acetyltransferase (PAT) encoding gene from S.viridochromogenes. A- ZSR500/502 Monsanto Company Introduction of amodified 5-enol- 26 pyruvylshikimate-3-phosphate synthase (EPSPS) and agene from Achromobacter sp that degrades glyphosate by conversion toaminomethylphosphonic acid (AMPA) and glyoxylate by interspecificcrossing with GT73. A- EE-1 Insect resistance (Cry1Ac) 27 A- 55-1/63-1Cornell University Papaya ringspot virus (PRSV) resistant papaya 28produced by inserting the coat protein (CP) encoding sequences from thisplant potyvirus. A- X17-2 University of Florida Papaya ringspot virus(PRSV) resistant papaya 29 produced by inserting the coat protein (CP)encoding sequences from PRSV isolate H1K with a thymidine inserted afterthe initiation codon to yield a frameshift. Also contains nptII as aselectable marker. A- RM3-3, RM3-4, Bejo Zaden BV Male sterility was viainsertion of the barnase 30 RM3-6 ribonuclease gene from Bacillusamyloliquefaciens; PPT resistance was via the bar gene from S.hygroscopicus, which encodes the PAT enzyme. A- A, B Agritope Inc.Reduced accumulation of S-adenosylmethionine 32 (SAM), and consequentlyreduced ethylene synthesis, by introduction of the gene encoding S-adenosylmethionine hydrolase. A- CZW-3 Asgrow (USA); Seminis Cucumbermosiac virus (CMV), zucchini yellows 33 Vegetable Inc. (Canada) mosaic(ZYMV) and watermelon mosaic virus (WMV) 2 resistant squash (Curcurbitapepo) produced by inserting the coat protein (CP) encoding sequencesfrom each of these plant viruses into the host genome. A- ZW20 Upjohn(USA); Seminis Zucchini yellows mosaic (ZYMV) and 34 Vegetable Inc.(Canada) watermelon mosaic virus (WMV) 2 resistant squash (Curcurbitapepo) produced by inserting the coat protein (CP) encoding sequencesfrom each of these plant potyviruses into the host genome. A- 66Florigene Pty Ltd. Delayed senescence and sulfonylurea herbicide 35tolerant carnations produced by inserting a truncated copy of thecarnation aminocyclopropane cyclase (ACC) synthase encoding gene inorder to suppress expression of the endogenous unmodified gene, which isrequired for normal ethylene biosynthesis. Tolerance to sulfonyl ureaherbicides was via the introduction of a chlorsulfuron tolerant versionof the acetolactate synthase (ALS) encoding gene from tobacco. A- 4, 11,15, 16 Florigene Pty Ltd. Modified colour and sulfonylurea herbicide 36tolerant carnations produced by inserting two anthocyanin biosyntheticgenes whose expression results in a violet/mauve colouration. Toleranceto sulfonyl urea herbicides was via the introduction of a chlorsulfurontolerant version of the acetolactate synthase (ALS) encoding gene fromtobacco. A- 959A, 988A, Florigene Pty Ltd. Introduction of twoanthocyanin biosynthetic 37 1226A, 1351A, genes to result in aviolet/mauve colouration; 1363A, 1400A Introduction of a variant form ofacetolactate synthase (ALS). A- 3560.4.3.5 Glyphosate/ALSinhibitor-tolerance; WO 38 2008002872 A- A2704-12, A2704- BayerCropScience Glufosinate ammonium herbicide tolerant soybean 39 21(Aventis produced by inserting a modified phosphinothricinCropScience(AgrEvo)) acetyltransferase (PAT) encoding gene from the soilbacterium Streptomyces viridochromogenes.; WO 2006/108674 A- A5547-127Bayer CropScience Glufosinate ammonium herbicide tolerant soybean 40(Aventis produced by inserting a modified phosphinothricinCropScience(AgrEvo)) acetyltransferase (PAT) encoding gene from the soilbacterium Streptomyces viridochromogenes. A- A5547-35 Bayer CropScienceGlufosinate tolerance; WO 2006/108675 41 (Aventis CropScience(AgrEvo))A- DP-305423-1 Pioneer Hi-Bred High oleic acid/ALS inhibitor tolerance;42 International Inc. A- DP356043 Pioneer Hi-Bred Soybean event with twoherbicide tolerance genes: 43 International Inc. glyphosateN-acetlytransferase, which detoxifies glyphosate, and a modifiedacetolactate synthase (A A- G94-1, G94-19, DuPont Canada High oleic acidsoybean produced by inserting a 44 G168 Agricultural Products secondcopy of the fatty acid desaturase (GmFad2- 1) encoding gene fromsoybean, which resulted in “silencing” of the endogenous host gene. A-GTS 40-3-2 Monsanto Company Glyphosate tolerant soybean variety producedby 45 inserting a modified 5-enolpyruvylshikimate-3- phosphate synthase(EPSPS) encoding gene from the soil bacterium Agrobacterium tumefaciens.A- GU262 Bayer CropScience Glufosinate ammonium herbicide tolerantsoybean 46 (Aventis produced by inserting a modified phosphinothricinCropScience(AgrEvo)) acetyltransferase (PAT) encoding gene from the soilbacterium Streptomyces viridochromogenes. A- MON87701 Monsanto Companyinsect resistance (CryIac); WO 2009064652 47 A- MON87705 MonsantoCompany altered fatty acid levels (mid-oleic and low 48 saturate); WO2010037016 A- MON87754 Monsanto Company increased oil content; 49 A-MON87769 Monsanto Company stearidonic acid (SDA) comprising oil; 50 A-MON89788 Monsanto Company Glyphosate-tolerant soybean produced by 51inserting a modified 5-enolpyruvylshikimate-3- phosphate synthase(EPSPS) encoding aroA (epsps) gene from Agrobacterium tumefaciens CP4;A- MON89788, Monsanto Company Glyphosate tolerance, WO2006130436 52MON19788 A- OT96-15 Agriculture & Agri-Food Low linolenic acid soybeanproduced through 53 Canada traditional cross-breeding to incorporate thenovel trait from a naturally occurring fan1 gene mutant that wasselected for low linolenic acid. A- W62, W98 Bayer CropScienceGlufosinate ammonium herbicide tolerant soybean 54 (Aventis produced byinserting a modified phosphinothricin CropScience(AgrEvo))acetyltransferase (PAT) encoding gene from the soil bacteriumStreptomyces hygroscopicus. A- 15985 Monsanto Company Insect resistantcotton derived by transformation 55 of the DP50B parent variety, whichcontained event 531 (expressing Cry1Ac protein), with purified plasmidDNA containing the cry2Ab gene from B. thuringiensis subsp. kurstaki. A-1143-14A Insect resistance (Cry1Ab) 56 A- 1143-51B Insect resistance(Cry1Ab) 57 A- 19-51A DuPont Canada Introduction of a variant form ofacetolactate 58 Agricultural Products synthase (ALS). A- 281-24-236 DOWAgroSciences LLC Insect-resistant cotton produced by inserting the 59cry1F gene from Bacillus thuringiensis var. aizawai. The PAT encodinggene from Streptomyces viridochromogenes was introduced as a selectablemarker. A- 3006-210-23 DOW AgroSciences LLC Insect-resistant cottonproduced by inserting the 60 cry1Ac gene from Bacillusthuringiensissubsp. kurstaki. The PAT encoding gene from Streptomycesviridochromogenes was introduced as a selectable marker. A- 31807/31808Calgene Inc. Insect-resistant and bromoxynil herbicide tolerant 61cotton produced by inserting the cry1Ac gene from Bacillus thuringiensisand a nitrilase encoding gene from Klebsiella pneumoniae. A- BXN CalgeneInc. Bromoxynil herbicide tolerant cotton produced by 62 inserting anitrilase encoding gene from Klebsiella pneumoniae. A- CE43-67B Insectresistance (Cry1Ab) 63 A- CE44-69D Insect resistance (Cry1Ab) 64 A-CE46-02A Insect resistance (Cry1Ab) 65 A- Cot102 Syngenta Seeds, Inc.Insect-resistant cotton produced by inserting the 66 vip3A(a) gene fromBacillus thuringiensis AB88. The APH4 encoding gene from E. coli wasintroduced as a selectable marker.; A- COT202 Syngenta Seeds, Inc.Insect resistance (VIP3A) 67 A- Cot202 Syngenta Seeds, Inc. Insectresistance (VIP3) 68 A- Cot67B Syngenta Seeds, Inc. Insect-resistantcotton produced by inserting a 69 full-length cry1Ab gene from Bacillusthuringiensis. The APH4 encoding gene from E. coli was introduced as aselectable marker. A- DAS-21Ø23-5 × DOW AgroSciences LLC WideStrike ™, astacked insect-resistant cotton 70 DAS-24236-5 derived from conventionalcross-breeding of parental lines 3006-210-23 (OECD identifier:DAS-21Ø23-5) and 281-24-236 (OECD identifier: DAS-24236-5). A-DAS-21Ø23-5 × DOW AgroSciences LLC Stacked insect-resistant andglyphosate-tolerant 71 DAS-24236-5 × and Pioneer Hi-Bred cotton derivedfrom conventional cross-breeding MON88913 International Inc. ofWideStrike cotton (OECD identifier: DAS- 21Ø23-5 × DAS-24236-5) withMON88913, known as RoundupReady Flex (OECD identifier: MON-88913-8). A-DAS-21Ø23-5 × DOW AgroSciences LLC WideStrike ™/Roundup Ready ® cotton,a stacked 72 DAS-24236-5 × insect-resistant and glyphosate-tolerantcotton MON-Ø1445-2 derived from conventional cross-breeding ofWideStrike cotton (OECD identifier: DAS- 21Ø23-5 × DAS-24236-5) withMON1445 (OECD identifier: MON-Ø1445-2). A- EE-GH3 Glyphosate tolerance73 A- EE-GH5 Insect resistance (Cry1Ab) 74 A- EE-GH6 Insect resistance(cry2Ae) 75 A- event 281-24-236 Insect resistance (Cry1F) 76 A- Event-1JK Agri Genetics Ltd Insect-resistant cotton produced by inserting the77 (India) cry1Ac gene from Bacillus thuringiensis subsp. kurstaki HD-73(B.t.k.). A- event3006-210-23 Insect resistance (Cry1Ac) 78 A- GBH614Bayer CropScience Glyphosate herbicide tolerant cotton produced by 79(Aventis inserting 2mepsps gene into variety Coker312 byCropScience(AgrEvo)) Agrobacterium under the control of Ph4a748At andTPotpC A- LLCotton25 Bayer CropScience Glufosinate ammonium herbicidetolerant cotton 80 (Aventis produced by inserting a modifiedphosphinothricin CropScience(AgrEvo)) acetyltransferase (PAT) encodinggene from the soil bacterium Streptomyces hygroscopicus; WO 2003013224,WO 2007/017186 A- LLCotton25 × Bayer CropScience Stacked herbicidetolerant and insect resistant 81 MON15985 (Aventis cotton combiningtolerance to glufosinate CropScience(AgrEvo)) ammonium herbicide fromLLCotton25 (OECD identifier: ACS-GHØØ1-3) with resistance to insectsfrom MON15985 (OECD identifier: MON-15985-7) A- MON 15985 Insectresistance (Cry1A/Cry2Ab) 82 A- MON1445/1698 Monsanto Company Glyphosateherbicide tolerant cotton produced by 83 inserting a naturallyglyphosate tolerant form of the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) from A. tumefaciens strain CP4.A- MON15985 × Monsanto Company Stacked insect resistant and glyphosatetolerant 84 MON88913 cotton produced by conventional cross-breeding ofthe parental lines MON88913 (OECD identifier: MON-88913-8) and 15985(OECD identifier: MON-15985-7). Glyphosate tolerance is derived fromMON88913 which contains two genes encoding the enzyme5-enolypyruvylshikimate-3- phosphate synthase (EPSPS) from the CP4strain of Agrobacterium tumefaciens. Insect resistance is derivedMON15985 which was produced by transformation of the DP50B parentvariety, which contained event 531 (expressing Cry1Ac protein), withpurified plasmid DNA containing the cry2Ab gene from B. thuringiensissubsp. kurstaki. A- MON-15985-7 × Monsanto Company Stacked insectresistant and herbicide tolerant 85 MON-Ø1445-2 cotton derived fromconventional cross-breeding of the parental lines 15985 (OECDidentifier: MON-15985-7) and MON1445 (OECD identifier: MON-Ø1445-2). A-MON531/757/1076 Monsanto Company Insect-resistant cotton produced byinserting the 86 cry1Ac gene from Bacillus thuringiensis subsp. kurstakiHD-73 (B.t.k.). A- LLcotton25 Glufosinate resistance 87 A- MON88913Monsanto Company Glyphosate herbicide tolerant cotton produced by 88inserting two genes encoding the enzyme 5-enolypyruvylshikimate-3-phosphate synthase (EPSPS) from the CP4 strainof Agrobacterium tumefaciens,; WO 2004/072235 A- MON-ØØ531-6 × MonsantoCompany Stacked insect resistant and herbicide tolerant 89 MON-Ø1445-2cotton derived from conventional cross-breeding of the parental linesMON531 (OECD identifier: MON-ØØ531-6) and MON1445 (OECD identifier:MON-Ø1445-2). A- PV-GHGT07 Glyphosate tolerance 90 (1445) A- T304-40Insect-resistance (Cry1Ab) 91 A- T342-142 Insect resistance (Cry1Ab) 92A- X81359 BASF Inc. Tolerance to imidazolinone herbicides by 93selection of a naturally occurring mutant. A- RH44 BASF Inc. Selectionfor a mutagenized version of the enzyme 94 acetohydroxyacid synthase(AHAS), also known as acetolactate synthase (ALS) or acetolactatepyruvate-lyase. A- FP967 University of A variant form of acetolactatesynthase (ALS) was 95 Saskatchewan, Crop Dev. obtained from achlorsulfuron tolerant line of A. Centre thaliana and used to transformflax. A- 5345 Monsanto Company Resistance to lepidopteran pests throughthe 96 introduction of the cry1Ac gene from Bacillus thuringiensissubsp. Kurstaki. A- 8338 Monsanto Company Introduction of a genesequence encoding the 97 enzyme 1-amino-cyclopropane-1-carboxylic aciddeaminase (ACCd) that metabolizes the precursor of the fruit ripeninghormone ethylene. A- 1345-4 DNA Plant Technology Delayed ripeningtomatoes produced by inserting 98 Corporation an additional copy of atruncated gene encoding 1- aminocyclopropane-1-carboxyllic acid (ACC)synthase, which resulted in downregulation of the endogenous ACCsynthase and reduced ethylene accumulation. A- 35 1 N Agritope Inc.Introduction of a gene sequence encoding the 99 enzymeS-adenosylmethionine hydrolase that metabolizes the precursor of thefruit ripening hormone ethylene A- B, Da, F Zeneca Seeds Delayedsoftening tomatoes produced by inserting 100 a truncated version of thepolygalacturonase (PG) encoding gene in the sense or anti-senseorientation in order to reduce expression of the endogenous PG gene, andthus reduce pectin degradation. A- FLAVR SAVR Calgene Inc. Delayedsoftening tomatoes produced by inserting 101 an additional copy of thepolygalacturonase (PG) encoding gene in the anti-sense orientation inorder to reduce expression of the endogenous PG gene and thus reducepectin degradation. A- J101, J163 Monsanto Company and Glyphosateherbicide tolerant alfalfa (lucerne) 102 Forage Genetics produced byinserting a gene encoding the enzyme International5-enolypyruvylshikimate-3-phosphate synthase (EPSPS) from the CP4 strainof Agrobacterium tumefaciens. A- C/F/93/08-02 Societe National Toleranceto the herbicides bromoxynil and 103 d'Exploitation des Tabacset ioxynilby incorporation of the nitrilase gene from Allumettes Klebsiellapneumoniae. A- Vector 21-41 Vector Tobacco Inc. Reduced nicotine contentthrough introduction of 104 a second copy of the tobacco quinolinic acidphosphoribosyltransferase (QTPase) in the antisense orientation. TheNPTII encoding gene from E. coli was introduced as a selectable markerto identify transformants. A- CL121, CL141, BASF Inc. Tolerance to theimidazolinone herbicide, 105 CFX51 imazethapyr, induced by chemicalmutagenesis of the acetolactate synthase (ALS) enzyme using ethylmethanesulfonate (EMS). A- GAT-OS2 Glufosinate tolerance 106 A- GAT-OS3Glufosinate tolerance 107 A- IMINTA-1, BASF Inc. Tolerance toimidazolinone herbicides induced by 108 IMINTA-4 chemical mutagenesis ofthe acetolactate synthase (ALS) enzyme using sodium azide. A- LLRICE06,Aventis CropScience Glufosinate ammonium herbicide tolerant rice 109LLRICE62 produced by inserting a modified phosphinothricinacetyltransferase (PAT) encoding gene from the soil bacteriumStreptomyces hygroscopicus). A- LLRICE601 Bayer CropScience Glufosinateammonium herbicide tolerant rice 110 (Aventis produced by inserting amodified phosphinothricin CropScience(AgrEvo)) acetyltransferase (PAT)encoding gene from the soil bacterium Streptomyces hygroscopicus). A-PE-7 Insect resistance (Cry1Ac) 111 A- PWC16 BASF Inc. Tolerance to theimidazolinone herbicide, 112 imazethapyr, induced by chemicalmutagenesis of the acetolactate synthase (ALS) enzyme using ethylmethanesulfonate (EMS). A- TT51 Insect resistance (Cry1Ab/Cry1Ac) 113 A-C5 United States Department Plum pox virus (PPV) resistant plum tree 114of Agriculture - produced through Agrobacterium-mediated AgriculturalResearch transformation with a coat protein (CP) gene from Service thevirus. A- ATBT04-6, Monsanto Company Colorado potato beetle resistantpotatoes produced 115 ATBT04-27, by inserting the cry3A gene fromBacillus ATBT04-30, thuringiensis (subsp. Tenebrionis). ATBT04-31,ATBT04-36, SPBT02-5, SPBT02-7 A- BT6, BT10, BT12, Monsanto CompanyColorado potato beetle resistant potatoes produced 116 BT16, BT17, byinserting the cry3A gene from Bacillus BT18, BT23 thuringiensis (subsp.Tenebrionis). A- RBMT15-101, Monsanto Company Colorado potato beetle andpotato virus Y (PVY) 117 SEMT15-02, resistant potatoes produced byinserting the cry3A SEMT15-15 gene from Bacillus thuringiensis (subsp.Tenebrionis) and the coat protein encoding gene from PVY. A- RBMT21-129,Monsanto Company Colorado potato beetle and potato leafroll virus 118RBMT21-350, (PLRV) resistant potatoes produced by inserting RBMT22-082the cry3A gene from Bacillus thuringiensis (subsp. Tenebrionis) and thereplicase encoding gene from PLRV. A- EH92-527 BASF Plant Science Cropcomposition; Amflora; Unique EU identifier: 119 BPS-25271-9 A- AP205CLBASF Inc. Selection for a mutagenized version of the enzyme 120acetohydroxyacid synthase (AHAS), also known as acetolactate synthase(ALS) or acetolactate pyruvate-lyase. A- AP602CL BASF Inc. Selection fora mutagenized version of the enzyme 121 acetohydroxyacid synthase(AHAS), also known as acetolactate synthase (ALS) or acetolactatepyruvate-lyase. A- BW255-2, BW238-3 BASF Inc. Selection for amutagenized version of the enzyme 122 acetohydroxyacid synthase (AHAS),also known as acetolactate synthase (ALS) or acetolactatepyruvate-lyase. A- BW7 BASF Inc. Tolerance to imidazolinone herbicidesinduced by 123 chemical mutagenesis of the acetohydroxyacid synthase(AHAS) gene using sodium azide. A- Event 1 Fusarium resistance(trichothecene 3-O- 124 acetyltransferase); CA 2561992 A- JOPLIN1disease (fungal) resistance (trichothecene 3-O- 125 acetyltransferase);US 2008064032 A- MON71800 Monsanto Company Glyphosate tolerant wheatvariety produced by 126 inserting a modified 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) encoding gene from the soil bacteriumAgrobacterium tumefaciens, strain CP4. A- SWP965001 Cyanamid CropSelection for a mutagenized version of the enzyme 127 Protectionacetohydroxyacid synthase (AHAS), also known as acetolactate synthase(ALS) or acetolactate pyruvate-lyase. A- Teal 11A BASF Inc. Selectionfor a mutagenized version of the enzyme 128 acetohydroxyacid synthase(AHAS), also known as acetolactate synthase (ALS) or acetolactatepyruvate-lyase. A- 176 Syngenta Seeds, Inc. Insect-resistant maizeproduced by inserting the 129 cry1Ab gene from Bacillus thuringiensissubsp. kurstaki. The genetic modification affords resistance to attackby the European corn borer (ECB). A- 3272 Self processing corn(alpha-amylase) 130 A- 3751IR Pioneer Hi-Bred Selection of somaclonalvariants by culture of 131 International Inc. embryos on imidazolinonecontaining media. A- 676, 678, 680 Pioneer Hi-Bred Male-sterile andglufosinate ammonium herbicide 132 International Inc. tolerant maizeproduced by inserting genes encoding DNA adenine methylase andphosphinothricin acetyltransferase (PAT) from Escherichia coli andStreptomyces viridochromogenes, respectively. A- ACS-ZMØØ3-2 × BayerCropScience Stacked insect resistant and herbicide tolerant corn 133MON-ØØ81Ø-6 (Aventis hybrid derived from conventional cross-breedingCropScience(AgrEvo)) of the parental lines T25 (OECD identifier: ACS-ZMØØ3-2) and MON810 (OECD identifier: MON-ØØ81Ø-6). A- B16 Glufosinateresistance 134 A- B16 (DLL25) Dekalb Genetics Glufosinate ammoniumherbicide tolerant maize 135 Corporation produced by inserting the geneencoding phosphinothricin acetyltransferase (PAT) from Streptomyceshygroscopicus. A- BT11 (X4334CBR, Syngenta Seeds, Inc. Insect-resistantand herbicide tolerant maize 136 X4734CBR) produced by inserting thecry1Ab gene from Bacillus thuringiensis subsp. kurstaki, and thephosphinothricin N-acetyltransferase (PAT) encoding gene from S.viridochromogenes. A- BT11 × GA21 Syngenta Seeds, Inc. Stacked insectresistant and herbicide tolerant 137 maize produced by conventionalcross breeding of parental lines BT11 (OECD unique identifier:SYN-BTØ11-1) and GA21 (OECD unique identifier: MON-ØØØ21-9). A- BT11 ×MIR162 Syngenta Seeds, Inc. Stacked insect resistant and herbicidetolerant 138 maize produced by conventional cross breeding of parentallines BT11 (OECD unique identifier: SYN-BTØ11-1) and MIR162 (OECD uniqueidentifier: SYN-IR162-4). Resistance to the European Corn Borer andtolerance to the herbicide glufosinate ammonium (Liberty) is derivedfrom BT11, which contains the cry1Ab gene from Bacillus thuringiensissubsp. kurstaki, and the phosphinothricin N-acetyltransferase (PAT)encoding gene from S. viridochromogenes. Resistance to otherlepidopteran pests, including H. zea, S. frugiperda, A. ipsilon, and S.albicosta, is derived from MIR162, which contains the vip3Aa gene fromBacillus thuringiensis strain AB88. A- BT11 × MIR162 × Syngenta Seeds,Inc. Bacillus thuringiensis Cry1Ab delta-endotoxin 139 MIR604 proteinand the genetic material necessary for its production (via elements ofvector pZO1502) in Event Bt11 corn (OECD Unique Identifier: SYN-BTØ11-1) × Bacillus thuringiensis Vip3Aa20 insecticidal protein and thegenetic material necessary for its production (via elements of vectorpNOV1300) in Event MIR162 maize (OECD Unique Identifier: SYN-IR162-4) ×modified Cry3A protein and the genetic material necessary for itsproduction (via elements of vector pZM26) in Event MIR604 corn (OECDUnique Identifier: SYN-IR6Ø4-5). A- BT11 × MIR604 Syngenta Seeds, Inc.Stacked insect resistant and herbicide tolerant 140 maize produced byconventional cross breeding of parental lines BT11 (OECD uniqueidentifier: SYN-BTØ11-1) and MIR604 (OECD unique identifier:SYN-IR6Ø5-5). Resistance to the European Corn Borer and tolerance to theherbicide glufosinate ammonium (Liberty) is derived from BT11, whichcontains the cry1Ab gene from Bacillus thuringiensis subsp. kurstaki,and the phosphinothricin N-acetyltransferase (PAT) encoding gene from S.viridochromogenes. Corn rootworm-resistance is derived from MIR604 whichcontains the mcry3A gene from Bacillus thuringiensis. A- BT11 × MIR604 ×Syngenta Seeds, Inc. Stacked insect resistant and herbicide tolerant 141GA21 maize produced by conventional cross breeding of parental linesBT11 (OECD unique identifier: SYN-BTØ11-1), MIR604 (OECD uniqueidentifier: SYN-IR6Ø5-5) and GA21 (OECD unique identifier: MON-ØØØ21-9).Resistance to the European Corn Borer and tolerance to the herbicideglufosinate ammonium (Liberty) is derived from BT11, which contains thecry1Ab gene from Bacillus thuringiensis subsp. kurstaki, and thephosphinothricin N-acetyltransferase (PAT) encoding gene from S.viridochromogenes. Corn rootworm-resistance is derived from MIR604 whichcontains the mcry3A gene from Bacillus thuringiensis. Tolerance toglyphosate herbcicide is derived from GA21 which contains a a modifiedEPSPS gene from maize A- CBH-351 Aventis CropScience Insect-resistantand glufosinate ammonium 142 herbicide tolerant maize developed byinserting genes encoding Cry9C protein from Bacillus thuringiensis subsptolworthi and phosphinothricin acetyltransferase (PAT) from Streptomyceshygroscopicus. A- DAS-06275-8 DOW AgroSciences LLC Lepidopteran insectresistant and glufosinate 143 ammonium herbicide-tolerant maize varietyproduced by inserting the cry1F gene from Bacillus thuringiensis varaizawai and the phosphinothricin acetyltransferase (PAT) fromStreptomyces hygroscopicus. A- DAS-59122-7 DOW AgroSciences LLC Cornrootworm-resistant maize produced by 144 and Pioneer Hi-Bred insertingthe cry34Ab1 and cry35Ab1 genes from International Inc. Bacillusthuringiensis strain PS149B1. The PAT encoding gene from Streptomycesviridochromogenes was introduced as a selectable marker; US 2006-070139A- DAS-59122-7 × DOW AgroSciences LLC Stacked insect resistant andherbicide tolerant 145 NK603 and Pioneer Hi-Bred maize produced byconventional cross breeding of International Inc. parental linesDAS-59122-7 (OECD unique identifier: DAS-59122-7) with NK603 (OECDunique identifier: MON-ØØ6Ø3-6). Corn rootworm-resistance is derivedfrom DAS-59122- 7 which contains the cry34Ab1 and cry35Ab1 genes fromBacillus thuringiensis strain PS149B1. Tolerance to glyphosateherbcicide is derived from NK603. A- DAS-59122-7 × DOW AgroSciences LLCStacked insect resistant and herbicide tolerant 146 TC1507 × NK603 andPioneer Hi-Bred maize produced by conventional cross breeding ofInternational Inc. parental lines DAS-59122-7 (OECD unique identifier:DAS-59122-7) and TC1507 (OECD unique identifier: DAS-Ø15Ø7-1) with NK603(OECD unique identifier: MON-ØØ6Ø3-6). Corn rootworm-resistance isderived from DAS-59122- 7 which contains the cry34Ab1 and cry35Ab1 genesfrom Bacillus thuringiensis strain PS149B1. Lepidopteran resistance andtoleraance to glufosinate ammonium herbicide is derived from TC1507.Tolerance to glyphosate herbcicide is derived from NK603. A- DAS-Ø15Ø7-1× DOW AgroSciences LLC Stacked insect resistant and herbicide tolerantcorn 147 MON-ØØ6Ø3-6 hybrid derived from conventional cross-breeding ofthe parental lines 1507 (OECD identifier: DAS- Ø15Ø7-1) and NK603 (OECDidentifier: MON- ØØ6Ø3-6). A- DBT418 Dekalb Genetics Insect-resistantand glufosinate ammonium 148 Corporation herbicide tolerant maizedeveloped by inserting genes encoding Cry1AC protein from Bacillusthuringiensis subsp kurstaki and phosphinothricin acetyltransferase(PAT) from Streptomyces hygroscopicus A- DK404SR BASF Inc. Somaclonalvariants with a modified acetyl-CoA- 149 carboxylase (ACCase) wereselected by culture of embryos on sethoxydim enriched medium. A-DP-098140-6 Glyphosate tolerance/ALS inhibitor tolerance 150 A-DP-Ø9814Ø-6 Pioneer Hi-Bred Corn line 98140 was genetically engineeredto 151 (Event 98140) International Inc. express the GAT4621 (glyphosateacetyltransferase) and ZM-HRA (modified version of a maize acetolactatesynthase) proteins. The GAT4621 protein, encoded by the gat4621 gene,confers tolerance to glyphosate-containing herbicides by acetylatingglyphosate and thereby rendering it non-phytotoxic. The ZM-HRA protein,encoded by the zm-hra gene, confers tolerance to the ALS-inhibitingclass of herbicides. A- Event 3272 Syngenta Seeds, Inc. Maize lineexpressing a heat stable alpha-amylase 152 gene amy797E for use in thedry-grind ethanol process. The phosphomannose isomerase gene from E.coli was used as a selectable marker. A- Event 98140 Pioneer Hi-BredMaize event expressing tolerance to glyphosate 153 International Inc.herbicide, via expression of a modified bacterial glyphosateN-acetlytransferase, and ALS- inhibiting herbicides, vial expression ofa modified form of the maize acetolactate synthase enzyme. A- EXP1910ITSyngenta Seeds, Inc. Tolerance to the imidazolinone herbicide, 154(formerly Zeneca Seeds) imazethapyr, induced by chemical mutagenesis ofthe acetolactate synthase (ALS) enzyme using ethyl methanesulfonate(EMS). A- FI117 Glyphosate resistance 155 A- GA21 Monsanto CompanyGlyphosate resistance: Introduction, by particle 156 bombardment, of amodified 5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS), an enzymeinvolved in the shikimate biochemical pathway for the production of thearomatic amino acids; A- GA21 × MON810 Monsanto Company Stacked insectresistant and herbicide tolerant corn 157 hybrid derived fromconventional cross-breeding of the parental lines GA21 (OECDidentifider: MON-ØØØ21-9) and MON810 (OECD identifier: MON-ØØ81Ø-6). A-GAT-ZM1 Glufosinate tolerance 158 A- GG25 Glyphosate resistance 159 A-GJ11 Glyphosate resistance; U.S. Pat. No. 6,040,497 160 A- IT PioneerHi-Bred Tolerance to the imidazolinone herbicide, 161 International Inc.imazethapyr, was obtained by in vitro selection of somaclonal variants.A- LY038 Monsanto Company Altered amino acid composition, specifically162 elevated levels of lysine, through the introduction of the cordapAgene, derived from Corynebacterium glutamicum, encoding the enzymedihydrodipicolinate synthase (cDHDPS); A- MIR162 Insect resistance 163A- MIR604 Syngenta Seeds, Inc. Corn rootworm resistant maize produced by164 transformation with a modified cry3A gene. The phosphomannoseisomerase gene from E. coli was used as a selectable marker; (Cry3a055)A- MIR604 × GA21 Syngenta Seeds, Inc. Stacked insect resistant andherbicide tolerant 165 maize produced by conventional cross breeding ofparental lines MIR604 (OECD unique identifier: SYN-IR6Ø5-5) and GA21(OECD unique identifier: MON-ØØØ21-9). Corn rootworm- resistance isderived from MIR604 which contains the mcry3A gene from Bacillusthuringiensis. Tolerance to glyphosate herbcicide is derived from GA21.A- MON80100 Monsanto Company Insect-resistant maize produced byinserting the 166 cry1Ab gene from Bacillus thuringiensis subsp.kurstaki. The genetic modification affords resistance to attack by theEuropean corn borer (ECB). A- MON802 Monsanto Company Insect-resistantand glyphosate herbicide tolerant 167 maize produced by inserting thegenes encoding the Cry1Ab protein from Bacillus thuringiensis and the5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) from A. tumefaciensstrain CP4. A- MON809 Pioneer Hi-Bred Resistance to European corn borer(Ostrinia 168 International Inc. nubilalis) by introduction of asynthetic cry1Ab gene. Glyphosate resistance via introduction of thebacterial version of a plant enzyme, 5-enolpyruvyl shikimate-3-phosphatesynthase (EPSPS). A- MON810 Monsanto Company Insect-resistant maizeproduced by inserting a 169 truncated form of the cry1Ab gene fromBacillus thuringiensis subsp. kurstaki HD-1. The genetic modificationaffords resistance to attack by the European corn borer (ECB); A- MON810× Monsanto Company Stacked insect resistant and glyphosate tolerant 170MON88017 maize derived from conventional cross-breeding of the parentallines MON810 (OECD identifier: MON-ØØ81Ø-6) and MON88017 (OECDidentifier: MON-88Ø17-3). European corn borer (ECB) resistance isderived from a truncated form of the cry1Ab gene from Bacillusthuringiensis subsp. kurstaki HD-1 present in MON810. Corn rootwormresistance is derived from the cry3Bb1 gene from Bacillus thuringiensissubspecies kumamotoensis strain EG4691 present in MON88017. Glyphosatetolerance is derived from a 5-enolpyruvylshikimate-3-phosphate synthase(EPSPS) encoding gene from Agrobacterium tumefaciens strain CP4 presentin MON88017. A- MON832 Monsanto Company Introduction, by particlebombardment, of 171 glyphosate oxidase (GOX) and a modified 5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS), an enzyme involvedin the shikimate biochemical pathway for the production of the aromaticamino acids. A- MON863 Monsanto Company Corn root worm resistant maizeproduced by 172 inserting the cry3Bb1 gene from Bacillus thuringiensissubsp. kumamotoensis. A- MON863 × Monsanto Company Stacked insectresistant corn hybrid derived from 173 MON810 conventionalcross-breeding of the parental lines MON863 (OECD identifier:MON-ØØ863-5) and MON810 (OECD identifier: MON-ØØ81Ø-6) A- MON863 ×Monsanto Company Stacked insect resistant and herbicide tolerant corn174 MON810 × NK603 hybrid derived from conventional cross-breeding ofthe stacked hybrid MON-ØØ863-5 × MON- ØØ81Ø-6 and NK603 (OECDidentifier: MON- ØØ6Ø3-6). A- MON863 × NK603 Monsanto Company Stackedinsect resistant and herbicide tolerant corn 175 hybrid derived fromconventional cross-breeding of the parental lines MON863 (OECDidentifier: MON-ØØ863-5) and NK603 (OECD identifier: MON-ØØ6Ø3-6). A-MON87460 Drought tolerance; Water deficit tolerance; 176 A- MON88017Monsanto Company Corn rootworm-resistant maize produced by 177 insertingthe cry3Bb1 gene from Bacillus thuringiensis subspecies kumamotoensisstrain EG4691. Glyphosate tolerance derived by inserting a5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) encoding gene fromAgrobacterium tumefaciens strain CP4 (Glyphosate tolerance); A- MON89034Monsanto Company Maize event expressing two different insecticidal 178proteins from Bacillus thuringiensis providing resistance to number oflepidopteran pests; nsect resistance (Lepidoptera-Cry1A.105-Cry2Ab); A-MON89034 × Monsanto Company Stacked insect resistant and glyphosatetolerant 179 MON88017 maize derived from conventional cross-breeding ofthe parental lines MON89034 (OECD identifier: MON-89Ø34-3) and MON88017(OECD identifier: MON-88Ø17-3). Resistance to Lepiopteran insects isderived from two crygenes present in MON89043. Corn rootworm resistanceis derived from a single cry genes and glyphosate tolerance is derivedfrom the 5- enolpyruvylshikimate-3-phosphate synthase (EPSPS) encodinggene from Agrobacterium tumefaciens present in MON88017. A- MON89034 ×Monsanto Company Stacked insect resistant and herbicide tolerant 180NK603 maize produced by conventional cross breeding of parental linesMON89034 (OECD identifier: MON-89Ø34-3) with NK603 (OECD uniqueidentifier: MON-ØØ6Ø3-6). Resistance to Lepiopteran insects is derivedfrom two crygenes present in MON89043. Tolerance to glyphosateherbcicide is derived from NK603. A- MON89034 × Monsanto Company Stackedinsect resistant and herbicide tolerant 181 TC1507 × maize produced byconventional cross breeding of MON88017 × parental lines: MON89034,TC1507, MON88017, DAS-59122-7 and DAS-59122. Resistance to theabove-ground and below-ground insect pests and tolerance to glyphosateand glufosinate-ammonium containing herbicides. A- MON-ØØ6Ø3-6 ×Monsanto Company Stacked insect resistant and herbicide tolerant corn182 MON-ØØ81Ø-6 hybrid derived from conventional cross-breeding of theparental lines NK603 (OECD identifier: MON-ØØ6Ø3-6) and MON810 (OECDidentifier: MON-ØØ81Ø-6). A- MON-ØØ81Ø-6 × Monsanto Company Stackedinsect resistant and enhanced lysine 183 LY038 content maize derivedfrom conventional cross- breeding of the parental lines MON810 (OECDidentifier: MON-ØØ81Ø-6) and LY038 (OECD identifier: REN-ØØØ38-3). A-MON-ØØ863-5 × Monsanto Company Stacked insect resistant and herbicidetolerant corn 184 MON-ØØ6Ø3-6 hybrid derived from conventionalcross-breeding of the parental lines MON863 (OECD identifier:MON-ØØ863-5) and NK603 (OECD identifier: MON-ØØ6Ø3-6). A- MON-ØØ863-5 ×Monsanto Company Stacked insect resistant corn hybrid derived from 185MON-ØØ81Ø-6 conventional cross-breeding of the parental lines MON863(OECD identifier: MON-ØØ863-5) and MON810 (OECD identifier: MON-ØØ81Ø-6)A- MON-ØØ863-5 × Monsanto Company Stacked insect resistant and herbicidetolerant corn 186 MON-ØØ81Ø-6 × hybrid derived from conventionalcross-breeding MON-ØØ6Ø3-6 of the stacked hybrid MON-ØØ863-5 × MON-ØØ81Ø-6 and NK603 (OECD identifier: MON- ØØ6Ø3-6). A- MON-ØØØ21-9 ×Monsanto Company Stacked insect resistant and herbicide tolerant corn187 MON-ØØ81Ø-6 hybrid derived from conventional cross-breeding of theparental lines GA21 (OECD identifider: MON-ØØØ21-9) and MON810 (OECDidentifier: MON-ØØ81Ø-6). A- MS3 Bayer CropScience Male sterility causedby expression of the barnase 188 (Aventis ribonuclease gene fromBacillus CropScience(AgrEvo)) amyloliquefaciens; PPT resistance was viaPPT- acetyltransferase (PAT). A- MS6 Bayer CropScience Male sterilitycaused by expression of the barnase 189 (Aventis ribonuclease gene fromBacillus CropScience(AgrEvo)) amyloliquefaciens; PPT resistance was viaPPT- acetyltransferase (PAT). A- NK603 Monsanto Company Introduction, byparticle bombardment, of a 190 modified 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), an enzyme involved in theshikimate biochemical pathway for the production of the aromatic aminoacids. A- NK603 × MON810 Monsanto Company Stacked insect resistant andherbicide tolerant corn 191 hybrid derived from conventionalcross-breeding of the parental lines NK603 (OECD identifier:MON-ØØ6Ø3-6) and MON810 (OECD identifier: MON-ØØ81Ø-6). A- NK603 × T25Monsanto Company Stacked glufosinate ammonium and glyphosate 192herbicide tolerant maize hybrid derived from conventional cross-breedingof the parental lines NK603 (OECD identifier: MON-ØØ6Ø3-6) and T25 (OECDidentifier: ACS-ZM003-2). A- PV-ZMGT32 Glyphosate tolerance 193 (NK603)A- E6611.32.1.38/ Pioneer Hi-Bred 1) M545: anther-specific 5126 (Zeamays) 194 DP-32138-1/ International Inc. promoter > fertilityrestoration Ms45 (Zea mays) 32138 coding sequence > fertilityrestoration Ms45 (Zea mays) 3′-untranslated region 2) ZM-AA1:polygalacturonase 47 (Zea mays) promoter > brittle-1 (Zea mays)chloroplast transit peptide > alpha-amylase-1 (Zea mays) truncatedcoding sequence > >In2-1 (Zea mays) 3′-untranslated region 3) DSRED2:35S (Cauliflower Mosaic Virus) enhancer > lipid transfer protein-2(Hordeum vulgare) promoter > red fluorescent protein (Dicosoma sp.)variant coding sequence > protein inhibitor II (Solanum tuberosum) 3′-untranslated region A- PV-ZMIR13 Insect resistance (Cry3Bb); 195(MON863) A- SYN-BTØ11-1 × Syngenta Seeds, Inc. Stacked insect resistantand herbicide tolerant 196 MON-ØØØ21-9 maize produced by conventionalcross breeding of parental lines BT11 (OECD unique identifier:SYN-BTØ11-1) and GA21 (OECD unique identifier: MON-ØØØ21-9). A- T14Bayer CropScience Glufosinate herbicide tolerant maize produced by 197(Aventis inserting the phosphinothricin N-acetyltransferaseCropScience(AgrEvo)) (PAT) encoding gene from the aerobic actinomyceteStreptomyces viridochromogenes. A- T14, T25 Bayer CropScienceGlufosinate herbicide tolerant maize produced by 198 (Aventis insertingthe phosphinothricin N-acetyltransferase CropScience(AgrEvo)) (PAT)encoding gene from the aerobic actinomycete Streptomycesviridochromogenes. A- T25 × MON810 Bayer CropScience Stacked insectresistant and herbicide tolerant corn 199 (Aventis hybrid derived fromconventional cross-breeding CropScience(AgrEvo)) of the parental linesT25 (OECD identifier: ACS- ZMØØ3-2) and MON810 (OECD identifier:MON-ØØ81Ø-6). A- TC1507 Mycogen (c/o Dow Insect-resistant andglufosinate ammonium 200 AgroSciences); Pioneer herbicide tolerant maizeproduced by inserting the (c/o Dupont) cry1F gene from Bacillusthuringiensis var. aizawai and the phosphinothricin N- acetyltransferaseencoding gene from Streptomyces viridochromogenes; Insect resistance(Cry1F); A- TC1507 × DAS- DOW AgroSciences LLC Stacked insect resistantand herbicide tolerant 201 59122-7 and Pioneer Hi-Bred maize produced byconventional cross breeding of International Inc. parental lines TC1507(OECD unique identifier: DAS-Ø15Ø7-1) with DAS-59122-7 (OECD uniqueidentifier: DAS-59122-7). Resistance to lepidopteran insects is derivedfrom TC1507 due the presence of the cry1F gene from Bacillusthuringiensis var. aizawai. Corn rootworm- resistance is derived fromDAS-59122-7 which contains the cry34Ab1 and cry35Ab1 genes from Bacillusthuringiensis strain PS149B1. Tolerance to glufosinate ammoniumherbcicide is derived from TC1507 from the phosphinothricin N-acetyltransferase encoding gene from Streptomyces viridochromogenes. A-VIP1034 Insect resistance; 202 A- MS-B2 Male sterility 203 A-MS-BN1/RF-BN1 Male sterility/restoration 204 A- RT73 Glyphosateresistance 205 A- MON 87708 MONSANTO Dicamba herbicide tolerance,transformation 206 TECHNOLOGY LLC vector PV-GMHT4355 1) DMO: full lengthtranscript (Peanut Chlorotic Streak Virus) promoter > tobacco Etch Virusleader > ribulose 1,5-biphosphate carboxylase small subunit (Pisumsativum) chloroplast transit peptide > dicamba mono-oxygenase(Stenotrophomonas maltophilia) coding sequence >ribulose-1,5-bisphosphate carboxylase small subunit E9 (Pisum sativum)3′- untranslated region. A CP4 epsps chimeric gene contained within asecond T-DNA on the transformation vector used was segregated away. A-EE-GM3/FG72 BAYER BIOSCIENCE 1) Ph4a748 ABBC: sequence including the 207NV [BE]; MS promoter region of the histone H4 gene of TECHNOLOGIES LLCArabidopsis thaliana, containing an internal [US] duplication > 5′tev:sequence including the leader sequence of the tobacco etch virus > TPotpY: coding sequence of an optimized transit peptide derivative (position55 changed into Tyrosine), containing sequence of the RuBisCO smallsubunit genes of Zea mays (corn) and Helianthus annuus (sunflower) >hppdPf W336: the coding sequence of the 4-hydroxyphenylpyruvatedioxygenase of Pseudomonas fluorescens strain A32 modified by thereplacement of the amino acid Glycine 336 with a Tryptophane > 3′nos:sequence including the 3′ untranslated region of the nopaline synthasegene from the T-DNA of pTiT37 of Agrobacterium tumefaciens. 2) Ph4a748:sequence including the promoter region of the histone H4 gene ofArabidopsis thaliana > intron1 h3At: first intron of gene II of thehistone H3.III variant of Arabidopsis thaliana > TPotp C: codingsequence of the optimized transit peptide, containing sequence of theRuBisCO small subunit genes of Zea mays (corn) and Helianthus annuus(sunflower) > 2mepsps: the coding sequence of the double-mutant 5-enol-pyruvylshikimate-3-phosphate synthase gene of Zea mays > 3′histonAt:sequence including the 3′ untranslated region of the histone H4 gene ofArabidopsis thaliana A- 416/pDAB4468- DOW AGROSCIENCES A novel aad-12transformation event for herbicide 208 0416 LLC tolerance in soybeanplants - referred to herein as pDAB4468-0416. The aad-12 gene(originally from Delftia acidovorans) encodes the aryloxyalkanoatedioxygenase (AAD-12) protein. The trait confers tolerance to 2,4-dichlorophenoxyacetic acid, for example, and to pyridyloxyacetateherbicides. The aad-12 gene, itself, for herbicide tolerance in plantswas first disclosed in WO 2007/053482. A- 127 ALS/AHASinhibitor-tolerance 209 A- A5547-35 Glufosinate tolerance 210 A-A2704-12 Glufosinate tolerance 211 A- Kefeng No. 6 CHINA NAT RICE RESTransgenic rice Kefeng 6 is a transformation event 212 INST containingtwo insect-resistant genes, cry1Ac and SCK (modified CpTI gene) inChina. A- 17053 Glyphosate tolerance 213 A- 17314 Glyphosate tolerance214 A- Event 1 Fusarium resistance (trichothecene 3-O- 215acetyltransferase) A- JOPLIN1 disease (fungal) resistance (trichothecene3-O- 216 acetyltransferase) A- DAS-40278-9 DOW AgroSciences LLC RB7MARv3 > zmUbiquitin 1 217 promoter > aad1 > zmPER5 3′UTR > RB 7 MARv4.The aad-1 gene confers tolerance to 2,4- dichlorophenoxyacetic acid andaryloxyphenoxypropionate (commonly referred to as “fop” herbicides suchas quizalofop) herbicides A- MIR604 Syngenta Participations 1) CRY3A:metallotionin-like gene (Zea mays) 218 AG promoter > delta-endotoxincry3a (Bacillus thuringiensis subsp. tenebrionis) coding sequence,modified to include a cathepsin-G protease recognition site and maizecodon optimized > nopaline synthase (Agrobacterium tumefaciens)3′-untranslated region 2) PMI: polyubiquitin (Zea mays) promoter (incl.first intron) > mannose-6- phosphate isomerase (Escherichia coli) codingsequence > nopaline synthase (Agrobacterium tumefaciens) 3′-untranslatedregion A- MON 87427 MONSANTO The transgene insert and expressioncassette of 219 TECHNOLOGY LLC MON 87427 comprises the promoter andleader from the cauliflower mosaic virus (CaMV) 35 S containing aduplicated enhancer region (P-e35S); operably linked to a DNA leaderderived from the first intron from the maize heat shock protein 70 gene(I-HSP70); operably linked to a DNA molecule encoding an N-terminalchloroplast transit peptide from the shkG gene from Arabidopsis thalianaEPSPS (Ts-CTP2); operably linked to a DNA molecule derived from the aroAgene from the Agrobacterium sp. strain CP4 and encoding the CP4 EPSPSprotein; operably linked to a 3′ UTR DNA molecule derived from thenopaline synthase (T-NOS) gene from Agrobacterium tumefaciens. A-DP-004114-3 Pioneer Hi-Bred cry1F, cry34Ab1, cry35Ab1, and pat:resistance to 220 International Inc. certain lepidopteran andcoleopteran pests, as well as tolerance to phosphinothricin. A-DP-032316-8 Pioneer Hi-Bred Cry1F, cry34Ab1, cry35Ab1, pat: resistanceto 221 International Inc. certain lepidopteran and coleopteran pests, aswell as tolerance to phosphinothricin A- DP-040416-8 a Pioneer Hi-BredCry1F, cry34Ab1, cry35Ab1, pat: resistance to 222 International Inc.certain lepidopteran and coleopteran pests, as well as tolerance tophosphinothricin A- DP-043A47-3 Pioneer Hi-Bred Cry1F, cry34Ab1,cry35Ab1, pat: resistance to 223 International Inc. certain lepidopteranand coleopteran pests, as well as tolerance to phosphinothricin A- 5307Insect (corn rootworm) resistance (FR8a) 224 Crop Patent Ref A-1Agrostis stolonifera US 2006-162007 Creeping Bentgrass A-2 Beta vulgaris(sugar beet) WO 2010076212 A-3 Beta vulgaris (sugar beet) WO 2004-074492A-4 Beta vulgaris (sugar beet) A-5 Beta vulgaris (sugar beet) A-6 Betavulgaris (sugar beet) US 2004-117870 A-7 Brassica napus (ArgentineCanola) A-8 Brassica napus (Argentine Canola) A-9 Brassica napus(Argentine Canola) A- Brassica 10 napus (Argentine Canola) A- Brassica11 napus (Argentine Canola) A- Brassica 12 napus (Argentine Canola) A-Brassica 13 napus (Argentine Canola) A- Brassica 14 napus (ArgentineCanola) A- Brassica 15 napus (Argentine Canola) A- Brassica 16 napus(Argentine Canola) A- Brassica 17 napus (Argentine Canola) A- Brassica18 napus (Argentine Canola) A- Brassica 19 napus (Argentine Canola) A-Brassica 20 napus (Argentine Canola) A- Brassica 21 napus (ArgentineCanola) A- Brassica 22 napus (Argentine Canola) A- Brassica WO 02/3683123 napus (Argentine Canola) A- Brassica 24 napus (Argentine Canola) A-Brassica rapa (Polish Canola) 25 A- Brassica rapa (Polish Canola) 26 A-Brinjal WO 2007/091277 27 A- Carica papaya (Papaya) 28 A- Carica papaya(Papaya) 29 A- Cichorium 30 intybus (Chicory) A- Cucumis melo (Melon) 32A- Cucurbita pepo (Squash) 33 A- Cucurbita pepo (Squash) 34 A- Dianthus35 caryophyllus (Carnation) A- Dianthus 36 caryophyllus (Carnation) A-Dianthus 37 caryophyllus (Carnation) A- Glycine max WO 2008002872, 38 L.(Soybean) US 2010184079 A- Glycine max WO 2006/108674 39 L. (Soybean) A-Glycine max 40 L. (Soybean) A- Glycine max WO 2006/108675 41 L.(Soybean) A- Glycine max WO 2008/054747 42 L. (Soybean) A- Glycine max43 L. (Soybean) A- Glycine max 44 L. (Soybean) A- Glycine max 45 L.(Soybean) A- Glycine max 46 L. (Soybean) A- Glycine max WO 2009064652 47L. (Soybean) A- Glycine max WO 2010037016 48 L. (Soybean) A- Glycine maxWO 2010024976 49 L. (Soybean) A- Glycine max WO 2009102873 50 L.(Soybean) A- Glycine max WO2006130436 51 L. (Soybean) A- Glycine max 52L. (Soybean) A- Glycine max 53 L. (Soybean) A- Glycine max 54 L.(Soybean) A- Gossypium hirsutum 55 L. (Cotton) A- Gossypium hirsutum WO2006/128569 56 L. (Cotton) A- Gossypium hirsutum WO 2006/128570 57 L.(Cotton) A- Gossypium hirsutum 58 L. (Cotton) A- Gossypium hirsutum 59L. (Cotton) A- Gossypium hirsutum 60 L. (Cotton) A- Gossypium hirsutum61 L. (Cotton) A- Gossypium hirsutum 62 L. (Cotton) A- Gossypiumhirsutum WO 2006/128573, 63 L. (Cotton) US 2011020828 A- Gossypiumhirsutum WO 2006/128571 64 L. (Cotton) A- Gossypium hirsutum WO2006/128572 65 L. (Cotton) A- Gossypium hirsutum US 2006-130175, 66 L.(Cotton) WO 2004039986, US 2010298553 A- Gossypium hirsutum US200918139967 L. (Cotton) A- Gossypium hirsutum US 2007-067868 68 L. (Cotton) A-Gossypium hirsutum 69 L. (Cotton) A- Gossypium hirsutum 70 L. (Cotton)A- Gossypium hirsutum 71 L. (Cotton) A- Gossypium hirsutum 72 L.(Cotton) A- Gossypium hirsutum WO 2007/017186 73 L. (Cotton) A-Gossypium hirsutum WO 2008/122406 74 L. (Cotton) A- Gossypium hirsutumWO 2008151780, 75 L. (Cotton) US 2010218281 A- Gossypium hirsutum WO2005/103266 76 L. (Cotton) A- Gossypium hirsutum 77 L. (Cotton) A-Gossypium hirsutum WO 2005/103266 78 L. (Cotton) A- Gossypium hirsutum79 L. (Cotton) A- Gossypium hirsutum 80 L. (Cotton) A- Gossypiumhirsutum 81 L. (Cotton) A- Gossypium hirsutum US 2004-250317 82 L.(Cotton) A- Gossypium hirsutum 83 L. (Cotton) A- Gossypium hirsutum 84L. (Cotton) A- Gossypium hirsutum 85 L. (Cotton) A- Gossypium hirsutum86 L. (Cotton) A- Gossypium hirsutum WO 2003013224 87 L. (Cotton) A-Gossypium hirsutum WO 2004/072235 88 L. (Cotton) A- Gossypium hirsutum89 L. (Cotton) A- Gossypium hirsutum US 2004-148666 90 L. (Cotton) A-Gossypium hirsutum WO 2008/122406, 91 L. (Cotton) US 2010077501 A-Gossypium hirsutum WO 2006/128568 92 L. (Cotton) A- Helianthus 93 annuus(Sunflower) A- Lens culinaris (Lentil) 94 A- Linum usitatissimum 95 L.(Flax, Linseed) A- Lycopersicon 96 esculentum (Tomato) A- Lycopersicon97 esculentum (Tomato) A- Lycopersicon 98 esculentum (Tomato) A-Lycopersicon 99 esculentum (Tomato) A- Lycopersicon 100 esculentum(Tomato) A- Lycopersicon 101 esculentum (Tomato) A- Medicago sativa(Alfalfa) 102 A- Nicotiana tabacum 103 L. (Tobacco) A- Nicotiana tabacum104 L. (Tobacco) A- Oryza sativa (Rice) 105 A- Oryza sativa (Rice) WO01/83818 106 A- Oryza sativa (Rice) US 2008-289060 107 A- Oryza sativa(Rice) 108 A- Oryza sativa (Rice) 109 A- Oryza sativa (Rice) 110 A-Oryza sativa (Rice) WO 2008/114282 111 A- Oryza sativa (Rice) 112 A-Oryza sativa (Rice) CN1840655 113 A- Prunus domestica (Plum) 114 A-Solanum tuberosum 115 L. (Potato) A- Solanum tuberosum 116 L. (Potato)A- Solanum tuberosum 117 L. (Potato) A- Solanum tuberosum 118 L.(Potato) A- Solanum tuberosum 119 L. (Potato) A- Triticum 120 aestivum(Wheat) A- Triticum 121 aestivum (Wheat) A- Triticum 122 aestivum(Wheat) A- Triticum 123 aestivum (Wheat) A- Triticum 124 aestivum(Wheat) A- Triticum 125 aestivum (Wheat) A- Triticum 126 aestivum(Wheat) A- Triticum 127 aestivum (Wheat) A- Triticum 128 aestivum(Wheat) A- Zea mays L. (Maize) 129 A- Zea mays L. (Maize) US2006-230473, 130 US 2010063265 A- Zea mays L. (Maize) 131 A- Zea mays L.(Maize) 132 A- Zea mays L. (Maize) 133 A- Zea mays L. (Maize) US2003-126634 134 A- Zea mays L. (Maize) 135 A- Zea mays L. (Maize) WO2010148268 136 A- Zea mays L. (Maize) 137 A- Zea mays L. (Maize) 138 A-Zea mays L. (Maize) 139 A- Zea mays L. (Maize) 140 A- Zea mays L.(Maize) 141 A- Zea mays L. (Maize) 142 A- Zea mays L. (Maize) 143 A- Zeamays L. (Maize) US 2006-070139, 144 US 2011030086 A- Zea mays L. (Maize)145 A- Zea mays L. (Maize) 146 A- Zea mays L. (Maize) 147 A- Zea mays L.(Maize) 148 A- Zea mays L. (Maize) 149 A- Zea mays L. (Maize) WO2008/112019, 150 US 2010240059 A- Zea mays L. (Maize) 151 A- Zea mays L.(Maize) 152 A- Zea mays L. (Maize) 153 A- Zea mays L. (Maize) 154 A- Zeamays L. (Maize) U.S. Pat. No. 6,040,497 155 A- Zea mays L. (Maize) U.S.Pat. No. 6,040,497 156 A- Zea mays L. (Maize) 157 A- Zea mays L. (Maize)WO 01/51654 158 A- Zea mays L. (Maize) U.S. Pat. No. 6,040,497 159 A-Zea mays L. (Maize) 160 A- Zea mays L. (Maize) 161 A- Zea mays L.(Maize) U.S. Pat. No. 7,157,281, 162 US 2010212051; US 2007028322 A- Zeamays L. (Maize) WO 2007142840 163 A- Zea mays L. (Maize) EP 1 737 290164 A- Zea mays L. (Maize) 165 A- Zea mays L. (Maize) 166 A- Zea mays L.(Maize) 167 A- Zea mays L. (Maize) 168 A- Zea mays L. (Maize) US2004-180373 169 A- Zea mays L. (Maize) 170 A- Zea mays L. (Maize) 171 A-Zea mays L. (Maize) 172 A- Zea mays L. (Maize) 173 A- Zea mays L.(Maize) 174 A- Zea mays L. (Maize) 175 A- Zea mays L. (Maize) WO2009/111263 176 A- Zea mays L. (Maize) WO2005059103 177 A- Zea mays L.(Maize) WO 2007140256 178 A- Zea mays L. (Maize) 179 A- Zea mays L.(Maize) 180 A- Zea mays L. (Maize) 181 A- Zea mays L. (Maize) 182 A- Zeamays L. (Maize) 183 A- Zea mays L. (Maize) 184 A- Zea mays L. (Maize)185 A- Zea mays L. (Maize) 186 A- Zea mays L. (Maize) 187 A- Zea mays L.(Maize) 188 A- Zea mays L. (Maize) 189 A- Zea mays L. (Maize) 190 A- Zeamays L. (Maize) 191 A- Zea mays L. (Maize) 192 A- Zea mays L. (Maize) US2007-056056 193 A- zea mays L. (Maize) WO 2009103049, 194 MX 2010008977A- Zea mays L. (Maize) US 2006-095986 195 A- Zea mays L. (Maize) 196 A-Zea mays L. (Maize) 197 A- Zea mays L. (Maize) 198 A- Zea mays L.(Maize) 199 A- Zea mays L. (Maize) U.S. Pat. No. 7,435,807 200 A- Zeamays L. (Maize) 201 A- Zea mays L. (Maize) WO 03/052073 202 A- Brassicassp WO 01/31042 203 A- Brassica ssp WO 01/41558 204 A- Brassica ssp WO02/36831 205 A- Glycine max WO 2011034704 206 L. (Soybean) A- Glycinemax WO 2011063411 207 L. (Soybean) A- Glycine max WO 2011066384 208 L.(Soybean) A- Glycine max WO 2010080829 209 L. (Soybean) A- Glycine maxWO 2006/108675 210 L. (Soybean) A- Glycine max WO 2006/108674 211 L.(Soybean) A- Oryza sativa (Rice) CN 101824411 212 A- Oryza sativa (Rice)WO 2010117737 213 A- Oryza sativa (Rice) WO 2010117735 214 A- Wheat CA2561992 215 A- Wheat US 2008064032 216 A- Zea mays L. (Maize) WO2011022469 217 A- Zea mays L. (Maize) US 2005216970, 218 US 2008167456,US 2011111420 A- Zea mays L. (Maize) WO 2011062904 219 A- Zea mays L.(Maize) US 2011154523 220 A- Zea mays L. (Maize) US 2011154524 221 A-Zea mays L. (Maize) US 20110154525 222 A- Zea mays L. (Maize)US20110154526 223 A- Zea mays L. (Maize) WO2010077816 224

Formulations

Suitable extenders and/or surfactants which may be contained in thecompositions according to the invention are all formulation auxiliarieswhich can customarily be used in plant treatment compositions.

When employing the active compounds of the formula (I) which can be usedaccording to the invention, the application rates can be varied within acertain range, depending on the type of application.

According to the invention, carrier is to be understood as meaning anatural or synthetic, organic or inorganic substance which is mixed orcombined with the active compounds for better applicability, inparticular for application to plants or plant parts. The carrier, whichmay be solid or liquid, is generally inert and should be suitable foruse in agriculture.

Suitable solid carriers are: for example ammonium salts and naturalground minerals, such as kaolins, clays, talc, chalk, quartz,attapulgite, montmorillonite or diatomaceous earth, and ground syntheticminerals, such as finely divided silica, alumina and natural orsynthetic silicates, resins, waxes, solid fertilizers, water, alcohols,especially butanol, organic solvents, mineral oils and vegetable oils,and also derivatives thereof. It is also possible to use mixtures ofsuch carriers. Solid carriers suitable for granules are: for examplecrushed and fractionated natural minerals, such as calcite, marble,pumice, sepiolite, dolomite, and also synthetic granules of inorganicand organic meals and also granules of organic material, such assawdust, coconut shells, maize cobs and tobacco stalks. Suitableemulsifiers and/or foam-formers are: for example nonionic and anionicemulsifiers, such as polyoxyethylene fatty acid esters, polyoxyethylenefatty alcohol ethers, for example alkylaryl polyglycol ethers,alkylsulphonates, alkyl sulphates, arylsulphonates, and also proteinhydrolysates. Suitable dispersants are: for example lignosulphite wasteliquors and methylcellulose.

Suitable liquefied gaseous extenders or carriers are liquids which aregaseous at ambient temperature and under atmospheric pressure, forexample aerosol propellants, such as butane, propane, nitrogen andcarbon dioxide.

Tackifiers, such as carboxymethylcellulose and natural and syntheticpolymers in the form of powders, granules and latices, such as gumarabic, polyvinyl alcohol, polyvinyl acetate, or else naturalphospholipids, such as cephalins and lecithins and syntheticphospholipids can be used in the formulations. Other possible additivesare mineral and vegetable oils.

If the extender used is water, it is also possible for example, to useorganic solvents as auxiliary solvents. Suitable liquid solvents areessentially: aromatic compounds, such as xylene, toluene oralkylnaphthalenes, chlorinated aromatic compounds or chlorinatedaliphatic hydrocarbons, such as chlorobenzenes, chloroethylenes ormethylene chloride, aliphatic hydrocarbons, such as cyclohexane orparaffins, for example mineral oil fractions, mineral and vegetableoils, alcohols, such as butanol or glycol, and also ethers and estersthereof, ketones, such as acetone, methyl ethyl ketone, methyl isobutylketone or cyclohexanone, strongly polar solvents, such asdimethylformamide and dimethyl sulphoxide, and also water.

The compositions according to the invention may comprise additionalfurther components, such as, for example, surfactants. Suitablesurfactants are emulsifiers, dispersants or wetting agents having ionicor nonionic properties, or mixtures of these surfactants. Examples ofthese are salts of polyacrylic acid, salts of lignosulphonic acid, saltsof phenolsulphonic acid or naphthalenesulphonic acid, polycondensates ofethylene oxide with fatty alcohols or with fatty acids or with fattyamines, substituted phenols (preferably alkylphenols or arylphenols),salts of sulphosuccinic esters, taurine derivatives (preferably alkyltaurates), phosphoric esters of polyethoxylated alcohols or phenols,fatty esters of polyols, and derivatives of the compounds containingsulphates, sulphonates and phosphates. The presence of a surfactant isrequired if one of the active compounds and/or one of the inert carriersis insoluble in water and when the application takes place in water. Theproportion of surfactants is between 5 and 40 percent by weight of thecomposition according to the invention.

It is possible to use colorants such as inorganic pigments, for exampleiron oxide, titanium oxide, Prussian blue, and organic dyes, such asalizarin dyes, azo dyes and metal phthalocyanine dyes, and tracenutrients, such as salts of iron, manganese, boron, copper, cobalt,molybdenum and zinc.

If appropriate, other additional components may also be present, forexample protective colloids, binders, adhesives, thickeners, thixotropicsubstances, penetrants, stabilizers, sequestering agents, complexformers. In general, the active compounds can be combined with any solidor liquid additive customarily used for formulation purposes.

In general, the compositions according to the invention comprise between0.05 and 99 percent by weight of the active compound combinationaccording to the invention, preferably between 10 and 70 percent byweight, particularly preferably between 20 and 50 percent by weight,most preferably 25 percent by weight.

Compounds of formula (I) be used as such or, depending on theirrespective physical and/or chemical properties, in the form of theirformulations or the use forms prepared therefrom, such as aerosols,capsule suspensions, cold-fogging concentrates, warm-foggingconcentrates, encapsulated granules, fine granules, ready-to-usesolutions, dustable powders, emulsifiable concentrates, oil-in-wateremulsions, water-in-oil emulsions, macrogranules, microgranules,oil-dispersible powders, oil-miscible flowable concentrates,oil-miscible liquids, foams, pastes, suspension concentrates,suspoemulsion concentrates, soluble concentrates, suspensions, wettablepowders, soluble powders, dusts and granules, water-soluble granules ortablets, wettable powders, natural products and synthetic substancesimpregnated with active compound, and also ULV cold-fogging andwarm-fogging formulations.

The formulations mentioned can be prepared in a manner known per se, forexample by mixing the active compounds or the active compoundcombinations with at least one additive. Suitable additives are allcustomary formulation auxiliaries, such as, for example, organicsolvents, extenders, solvents or diluents, solid carriers and fillers,surfactants (such as adjuvants, emulsifiers, dispersants, protectivecolloids, wetting agents and tackifiers), dispersants and/or binders orfixatives, preservatives, dyes and pigments, defoamers, inorganic andorganic thickeners, water repellents, if appropriate siccatives and UVstabilizers, gibberellins and also water and further processingauxiliaries. Depending on the formulation type to be prepared in eachcase, further processing steps such as, for example, wet grinding, drygrinding or granulation may be required.

Organic diluents that may be present are all polar and non-polar organicsolvents that are customarily used for such purposes. Preferred areketones, such as methyl isobutyl ketone and cyclohexanone, furthermoreamides, such as dimethylformamide and alkanecarboxamides, such asN,N-dimethyldecan-amide and N,N-dimethyloctanamide, furthermore cycliccompounds, such as N-methylpyrrolidone, N-octylpyrrolidone,N-dodecylpyrrolidone, N-octylcaprolactam, N-dodecylcaprolactam andbutyrolactone, additionally strongly polar solvents, such as dimethylsulphoxide, furthermore aromatic hydrocarbons, such as xylene,Solvesso™, mineral oils, such as white spirit, petroleum, alkylbenzenesand spindle oil, moreover esters, such as propylene glycol monomethylether acetate, dibutyl adipate, hexyl acetate, heptyl acetate,tri-n-butyl citrate and di-n-butyl phthalate, and furthermore alcohols,such as, for example, benzyl alcohol and 1-methoxy-2-propanol.

Solid carriers suitable for granules are: for example crushed andfractionated natural minerals, such as calcite, marble, pumice,sepiolite, dolomite, and also synthetic granules of inorganic andorganic meals and also granules of organic material, such as sawdust,coconut shells, maize cobs and tobacco stalks.

Suitable surfactants (adjuvants, emulsifiers, dispersants, protectivecolloids, wetting agents and tackifiers) are customary ionic andnonionic substances. Examples which may be mentioned are ethoxylatednonylphenols, polyalkylene glycol ethers of straight-chain or branchedalcohols, products of reactions of alkylphenols with ethylene oxideand/or propylene oxide, products of reactions of fatty amines withethylene oxide and/or propylene oxide, furthermore fatty esters,alkylsulphonates, alkyl sulphates, alkyl ether sulphates, alkyl etherphosphates, aryl sulphates, ethoxylated arylalkylphenols, such as, forexample, tristyrylphenol ethoxylates, furthermore ethoxylated andpropoxylated arylalkylphenols and also sulphated or phosphatedarylalkylphenol ethoxylates or ethoxy- and propoxylates. Mention mayfurthermore be made of natural and synthetic water-soluble polymers,such as lignosulphonates, gelatine, gum arabic, phospholipids, starch,hydrophobically modified starch and cellulose derivatives, in particularcellulose esters and cellulose ethers, furthermore polyvinyl alcohol,polyvinyl acetate, polyvinylpyrrolidone, polyacrylic acid,polymethacrylic acid and copolymers of (meth)acrylic acid and(meth)acrylic acid esters, and moreover also alkali metalhydroxide-neutralized copolymers of methacrylic acid and methacrylicester and condensates of optionally substituted naphthalenesulphonicacid salts with formaldehyde.

Suitable solid fillers and carriers are all substances customarily usedfor this purpose in crop pretection compositions. Inorganic particles,such as carbonates, silicates, sulphates and oxides having a meanparticle size of from 0.005 to 20 μm, particularly preferably from 0.02to 10 μm, may be mentioned as being preferred. Examples which may bementioned are ammonium sulphate, ammonium phosphate, urea, calciumcarbonate, calcium sulphate, magnesium sulphate, magnesium oxide,aluminium oxide, silicon dioxide, finely divided silicic acid, silicagels, natural and synthetic silicates and alumosilicates and vegetableproducts such as cereal meal, wood powder and cellulose powder.

The formulations generally comprise between 0.1 and 95% by weight ofactive compound, preferably between 0.5 and 90%.

The active compound combinations according to the invention can bepresent in commercial formulations and in the use forms prepared fromthese formulations as a mixture with other active compounds, such asinsecticides, attractants, sterilants, bactericides, acaricides,nematicides, fungicides, growth regulators or herbicides. A mixture withfertilizers is also possible.

The treatment according to the invention of the plants and plant partswith the active compound combinations or compositions is carried outdirectly or by action on their surroundings, habitat or storage spaceusing customary treatment methods, for example by dipping, spraying,atomizing, irrigating, evaporating, dusting, fogging, broadcasting,foaming, painting, spreading-on, watering (drenching), drip irrigatingand, in the case of propagation material. Preference is given toapplication by dipping, spraying, atomizing, irrigating, evaporating,dusting, fogging, broadcasting, foaming, painting, spreading-on,watering (drenching) and drip irrigating.

The application of the formulations is carried out in accordance withcustomary agricultural practice in a manner adapted to the applicationforms. Customary applications are, for example, dilution with water andspraying of the resulting spray liquor, application after dilution withoil, direct application without dilution, or soil application of carriergranules.

The active compound content of the application forms prepared from thecommercial formulations can vary within wide limits. The active compoundconcentration of the application forms can be from 0.0000001 up to 95%by weight of active compound, preferably between 0.0001 and 2% byweight.

The compositions according to the invention do not only compriseready-to-use compositions which can be applied with suitable apparatusto the plant, but also commercial concentrates which have to be dilutedwith water prior to use.

Application Methods

The treatment according to the invention of the plants and plant partswith compounds of formula (I) is carried out directly or by action ontheir surroundings, habitat or storage space using customary treatmentmethods, for example by dipping, spraying, atomizing, irrigating, steminjection, in-furrow application, evaporating, dusting, fogging,broadcasting, foaming, painting, spreading-on, watering (drenching),drip irrigating. It is furthermore possible to apply the activecompounds by the ultra-low volume method, or to inject the activecompound preparation or the active compound itself into the soil.

The control of nematodes which damage plants post-emergence is carriedout primarily by treating the soil and the above-ground parts of plantswith crop protection compositions. Owing to the concerns regarding apossible impact of the crop protection composition on the environmentand the health of humans and animals, there are efforts to reduce theamount of active compounds applied.

The nematicidal compositions according to the invention can be used forthe curative or protective control of nematodes. Accordingly, theinvention also relates to curative and protective methods forcontrolling nematodes using compounds of formula (I), which are appliedto the plant or plant parts, the fruit or the soil in which the plantsgrow. Preference is given to application onto the plant or the plantparts, the fruits or the soil.

The compositions according to the invention for controlling nematodes incrop protection comprise an active, but non-phytotoxic amount of thecompounds according to the invention. “Active, but non-phytotoxicamount” shall mean an amount of the composition according to theinvention which is sufficient to control or to completely kill the plantdisease caused by nematodes, which amount at the same time does notexhibit noteworthy symptoms of phytotoxicity. These application ratesgenerally may be varied in a broader range, which rate depends onseveral factors, e.g. the nematodes, the plant or crop, the climaticconditions and the ingredients of the composition according to theinvention.

The fact that the active compounds, at the concentrations required forthe controlling of plant diseases, are well tolerated by plants permitsthe treatment of aerial plant parts, of vegetative propagation materialand of the soil.

In a further embodiment the present invention relates to the use ofcompounds of formula (I) for controlling Meloidogyne incognita intomato.

In a further embodiment the present invention relates to the use ofcompounds of formula (I) for controlling Helicotylenchus sp. in tomato.

In a further embodiment the present invention relates to the use ofcompounds of formula (I) for controlling Meloidogyne hapla in potato.

In a further embodiment the present invention relates to the use ofcompounds of formula (I) for controlling Tylenchulus semipenetrans incitrus.

In a further embodiment the present invention relates to the use ofcompounds of formula (I) for controlling Radopholus similis in banana.

In a further embodiment the present invention relates to a method oftreatment comprising applying compounds of formula (I) as a plant drenchapplication for controlling nematodes.

In a further embodiment the present invention relates to a method oftreatment comprising applying compounds of formula (I) as a plant drenchapplication for controlling nematodes in tomato.

In a further embodiment the present invention relates to a method oftreatment comprising applying compounds of formula (I) as a plantin-furrow application for controlling nematodes.

In a further embodiment the present invention relates to a method oftreatment comprising applying compounds of formula (I) as a plantin-furrow application for controlling nematodes in potato.

In a further embodiment the present invention relates to a method oftreatment comprising applying compounds of formula (I) as a drenchapplication for controlling nematodes.

In a further embodiment the present invention relates to a method oftreatment comprising applying compounds of formula (I) as a drenchapplication for controlling nematodes in citrus.

In a further embodiment the present invention relates to a method oftreatment comprising applying compounds of formula (I) as a drenchapplication for controlling nematodes in banana.

In a further embodiment the present invention relates to a method oftreatment comprising applying compounds of formula (I) as a steminjection application for controlling nematodes.

In a further embodiment the present invention relates to a method oftreatment comprising applying compounds of formula (I) as a steminjection application for controlling nematodes in banana.

In a further embodiment the present invention relates to the use ofcompositions comprising compounds of formula (I) for controllingMeloidogyne incognita in tomato.

In a further embodiment the present invention relates to the use ofcompositions comprising compounds of formula (I) for controllingHelicotylenchus sp. in tomato.

In a further embodiment the present invention relates to the use ofcompositions comprising compounds of formula (I) for controllingMeloidogyne hapla in potato.

In a further embodiment the present invention relates to the use ofcompositions comprising compounds of formula (I) for controllingTylenchulus semipenetrans in citrus.

In a further embodiment the present invention relates to the use ofcompositions comprising compounds of formula (I) for controllingRadopholus similis in banana.

In a further embodiment the present invention relates to a method oftreatment comprising applying compositions comprising compounds offormula (I) as a plant drench application for controlling nematodes.

In a further embodiment the present invention relates to a method oftreatment comprising applying compositions comprising compounds offormula (I) as a plant drench application for controlling nematodes intomato.

In a further embodiment the present invention relates to a method oftreatment comprising applying compositions comprising compounds offormula (I) as a plant in-furrow application for controlling nematodes.

In a further embodiment the present invention relates to a method oftreatment comprising applying compositions comprising compounds offormula (I) as a plant in-furrow application for controlling nematodesin potato.

In a further embodiment the present invention relates to a method oftreatment comprising applying compositions comprising compounds offormula (I) as a drench application for controlling nematodes.

In a further embodiment the present invention relates to a method oftreatment comprising applying compositions comprising compounds offormula (I) as a drench application for controlling nematodes in citrus.

In a further embodiment the present invention relates to a method oftreatment comprising applying compositions comprising compounds offormula (I) as a drench application for controlling nematodes in banana.

In a further embodiment the present invention relates to a method oftreatment comprising applying compositions comprising compounds offormula (I) as a stem injection application for controlling nematodes.

In a further embodiment the present invention relates to a method oftreatment comprising applying compositions comprising compounds offormula (I) as a stem injection application for controlling nematodes inbanana.

The following synthesis examples illustrate the preparation of thecompounds of formula (I).

SYNTHESIS EXAMPLE A Preparation ofN-[1-(2,6-difluorophenyl)-1H-pyrazol-3-yl]-2-(trifluoromethyl)benzamide(compound (I-1-75))

Step 1: 1-(2,6-Difluorophenyl)-4,5-dihydro-1H-pyrazole-3-amine(intermediate (Ia-1))

2,6-Difluorophenylhydrazine hydrochloride (2.00 g) was initially chargedin ethanol (20 ml), sodium ethoxide (21% in ethanol, 3.02 g) was slowlyadded dropwise at room temperature, the mixture was stirred for 10 min,acrylonitrile (0.80 ml) was added and the mixture was heated underreflux overnight. The reaction mixture was then concentrated underreduced pressure, taken up in dichloromethane, washed with water, driedover sodium sulphate and concentrated to dryness under reduced pressure.What remained was 1.40 g of the title compound which was used withoutfurther purification for the next step.

Step 2: N-[1-(2,6-Difluorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]acetamide(intermediate (Ia-2))

With ice cooling, 1-(2,6-difluorophenyl)-4,5-dihydro-1H-pyrazole-3-amine(Ia-1) (1.40 g from previous step) was dissolved in acetic anhydride (6ml) and stirred at room temperature overnight. The mixture was thendiluted with ethyl acetate, washed with water, dried over sodiumsulphate and concentrated to dryness under reduced pressure. The residuewas purified by column chromatography on silica gel using the mobilephase cyclohexane/ethyl acetate (gradient=2 h from 100% cyclohexane to100% ethyl acetate). This gave 537 mg of the title compound. HPLC-MS:log P=1.46; mass (m/z): 240.0 (M+H)+; 1H-NMR (DMSO-D6) 1.99 (s, 3H),3.26 (t, 2H), 3.65 (t, 2H), 7.04-7.10 (m, 2H), 7.11-7.18 (m, 1H), 10.59(br. s, 1H).

Step 3: N-[1-(2,6-Difluorophenyl)-1H-pyrazol-3-yl]acetamide(intermediate (Ia-3))

N-[1-(2,6-Difluorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]acetamide (Ia-2)(200 mg) was initially charged in 1,4-dioxane (1 ml),2,3-dichloro-5,6-dicyano-1,4-benzoquinone (209 mg) was added and themixture was stirred at room temperature for 30 min. The reaction mixturewas filtered and the filtrate was concentrated to dryness under reducedpressure. The residue was purified by column chromatography on silicagel using the mobile phase cyclohexane/ethyl acetate (gradient=2 h from100% cyclohexane to 100% ethyl acetate). This gave 140 mg of the titlecompound.

HPLC-MS: log P=1.33; mass (m/z): 238.0 (M+H)+; 1H-NMR (CD3CN) 2.07 (s,3H), 6.84 (d, 1H), 7.14-7.20 (m, 2H), 7.47-7.53 (m, 1H), 7.65-7.66 (m,1H), 8.76 (br. s, 1H).

Step 4: 1-(2,6-Difluorophenyl)-1H-pyrazole-3-amine (intermediate (Ia-4))

N-[1-(2,6-Difluorophenyl)-1H-pyrazol-3-yl]acetamide (Ia-3) (50 mg) wasinitially charged in water (1 ml), concentrated hydrochloric acid (0.07ml) was added and the mixture was heated under reflux for 8 h. Thereaction mixture was then made alkaline with concentrated aqueous sodiumhydroxide solution and extracted with dichloromethane. The organic phasewas concentrated to dryness under reduced pressure. This gave 25 mg ofthe title compound.

HPLC-MS: log P=1.13; mass (m/z): 196.1 (M+H)+; 1H-NMR (CD3CN) 4.12 (br.s, 2H), 5.83 (d, 1H), 7.09-7.16 (m, 2H), 7.37-7.44 (m, 1H), 7.46-7.47(m, 1H).

Step 5:N-[1-(2,6-difluorophenyl)-1H-pyrazol-3-yl]-2-(trifluoromethyl)benzamide(compound (I-1-75))

1-(2,6-Difluorophenyl)-1H-pyrazole-3-amine (Ia-4) (1 g) was initiallycharged in dichloromethane (10 ml). The reaction mixture was cooled downto 0° C.; 2.142 mL of triethylamine were added. Then2-(trifluoromethyl)benzoyl chloride (1.175 g) was added dropwise with atemperature between 0° C. and 5° C. The reaction mixture was stirredovernight at room temperature. Some dichloromethane and water were thenadded. The organic phase was separated, dried and evaporated. Theresidue obtained was purified by column chromatography on silica gelusing a gradient of cyclohexane/ethyl acetate. This gave 1.2 g of thetitle compound.

HPLC-MS: log P=2.68; mass (m/z): 368.1 (M+H)+; 1H-NMR [CD3CN] 6.99 (d,1H), 7.16-7.22 (m, 2H), 7.47-7.54 (m, 1H), 7.65-7.76 (m, 4H), 7.80-7.82(m, 1H), 9.30 (br. s, 1H).

SYNTHESIS EXAMPLE B Preparation ofN-[1-(3,5-difluoropyridin-2-yl)-1H-pyrazol-3-yl]-2-(trifluoromethyl)benzamide(compound (I-1-140))

Step 1: 1-(3,5-Difluoropyridin-2-yl)-1H-pyrazole-3-amine (intermediate(Ib-1)

1H-Pyrazole-3-amine (1.80 g) was initially charged in acetonitrile (50ml), 2,3,5-trifluoropyridine (2.88 g) and potassium carbonate (5.99 g)were added and the mixture was heated under reflux overnight. Thereaction mixture was then concentrated under reduced pressure, taken upin dichloromethane, washed with water, dried over sodium sulphate andconcentrated to dryness under reduced pressure. The residue was purifiedby column chromatography on silica gel using the mobile phasecyclohexane/ethyl acetate (gradient=2 h from 100% cyclohexane to 100%ethyl acetate). This gave 610 mg of the title compound.

HPLC-MS: log P=0.81; mass (m/z): 197.1 (M+H)+; 1H-NMR (CD3CN) 4.27 (br.s, 2H), 5.88 (d, 1H), 7.56-7.62 (m, 1H), 7.99-8.00 (m, 1H), 8.17-8.18(m, 1H).

Step 2:N-[1-(3,5-difluoropyridin-2-yl)-1H-pyrazol-3-yl]-2-(trifluoromethyl)benzamide(compound (I-1-140))

1-(3,5-Difluoropyridin-2-yl)-1H-pyrazole-3-amine (Ib-1) (300 mg) wasinitially charged in dichloromethane (2 ml). The reaction mixture wascooled down to 0° C.; 0.640 ml of triethylamine were added. Then2-(trifluoromethyl)benzoyl chloride (0.256 ml) was added dropwise with atemperature between 0° C. and 5° C. The reaction mixture was stirredovernight at room temperature. Some dichloromethane and water were thenadded. The organic phase was separated, dried and evaporated. Theresidue obtained was purified by column chromatography on silica gelusing a gradient of cyclohexane/ethyl acetate. This gave 506 mg of thetitle compound.

HPLC-MS: log P=2.48; mass (m/z): 369.1 (M+H)+; 1H-NMR [CD3CN] 7.03 (d,1H), 7.62-7.70 (m, 4H), 7.77-7.79 (m, 1H), 8.20 (d, 1H), 8.25 (d, 1H),9.47 (br. s, 1H).

SYNTHESIS EXAMPLE C Preparation ofN-[2-(2,6-Difluorophenyl)-2H-1,2,3-triazol-4-yl]-2-(trifluoromethyl)benzamide(compound (I-2-35))

Step 1: 2-[2-(2,6-Difluorophenyl)hydrazinylidene]propanal oxime(intermediate (Ic-1))

0.1 mol of 2,6-difluorophenylhydrazine and 0.12 mol of isonitrosoacetonewere heated under reflux in ethanol for 3 h. After cooling to roomtemperature, the precipitated solid was filtered off, washed withethanol and dried. This gave the title compound (75% of theory)

Step 2: 2-(2,6-Difluorophenyl)-4-methyl-2H-1,2,3-triazole (intermediate(Ic-2))

A solution of 0.1 mol of the2-[2-(2,6-difluorophenyl)hydrazinylidene]propanal oxime (Ic-1) in aceticanhydride was heated slowly to 120° C. and stirred at this temperaturefor 2 h. Excess of acetic anhydride was removed on a rotary evaporator.The title compound was obtained (65% of theory) and was used withoutfurther purification.

Step 3: 2-(2,6-Difluorophenyl)-2H-1,2,3-triazole-4-carboxylic acid(intermediate (Ic-3))

0.2 mol of sodium dichromate was added to a well-stirred solution of 0.1mol of 2-(2,6-difluorophenyl)-4-methyl-2H-1,2,3-triazole (Ic-2) in 66%sulphuric acid. Each individual portion of dichromate was added onlyafter the yellow-orange colour of the Cr6+ in the flask had disappeared.Moreover, the portions were added such that the temperature in the flaskremained at about 80-90° C. The mixture was then heated for 1 h. Aftercooling, the mixture was poured into about the same amount of ice andallowed to stand overnight. The precipitated acid (Ic-3) was filteredoff, washed with water and dried. This gave the title compound (50% oftheory).

Step 4: Methyl 2-(2,6-difluorophenyl)-2H-1,2,3-triazole-4-carboxylate(intermediate (Ic-4))

Hydrogen chloride was bubbled for 2 h through a boiling solution of2-(2,6-difluorophenyl)-2H-1,2,3-triazole-4-carboxylic acid (Ic-3) inmethanol. After cooling, white crystals of the title compound werefiltered off (85% of theory).

Step 5: 2-(2,6-Difluorophenyl)-2H-1,2,3-triazole-4-carbohydrazide(intermediate (Ic-5))

Methyl 2-(2,6-difluorophenyl)-2H-1,2,3-triazole-4-carboxylate (Ic-4) wasboiled with an excess of 1.5 eq. of hydrazine hydrate in ethanol for 4h. After cooling, the crystals of the hydrazide (Ic-5) were boiled withwater and dried. This gave the title compound (90% of theory).

Step 6: 2-(2,6-Difluorophenyl)-2H-1,2,3-triazole-4-carbonylazide(intermediate (Ic-6))

An aqueous solution of sodium nitrite was added to a suspension of2-(2,6-Difluorophenyl)-2H-1,2,3-triazole-4-carbohydrazide (Ic-5) in 20%aqueous hydrochloric acid. After further stirring at 10° C., thecrystals of the acyl azide (Ic-6) were filtered off, washed with waterand dried at room temperature under reduced pressure. This gave thetitle compound (75% of theory).

Step 7: 2-(2,6-Difluorophenyl)-2H-1,2,3-triazole-4-carbonyl isocyanate(intermediate (Ic-7))

2-(2,6-Difluorophenyl)-2H-1,2,3-triazole-4-carbonyl azide (Ic-6) driedwas boiled in toluene until the evolution of gas had ended (about 2 h).The toluene was then removed on a rotary evaporator and the viscousresidue of the isocyanate (Ic-7) was directly ready for the next stepwithout further purification. This gave the title compound (90% oftheory).

Step 8: 2-(2,6-Difluorophenyl)-2H-1,2,3-triazole-4-amine (intermediate(Ic-8))

2-(2,6-Difluorophenyl)-2H-1,2,3-triazole-4-carbonyl isocyanate (Ic-7)was hydrolyzed by 30 min of boiling in hydrochloric acid. Residualvolatile substances were removed on a rotary evaporator, and the residuewas treated with sodium carbonate solution. The precipitated crystalswere filtered off, washed with water and recrystallized from hexane.This gave the title compound (70% of theory).

HPLC-MS: log P=1.16; mass (m/z): 197.0 (M+H)+; 1H-NMR (CD3CN) 5.46 (b,2H), 7.33-7.38 (m, 3H), 7.56-7.64 (m, 1H).

Step 9:N-[2-(2,6-Difluorophenyl)-2H-1,2,3-triazol-4-yl]-2-(trifluoromethyl)benzamide(Compound I-2-35)

2, 2-(2,6-difluorophenyl)-2H-1,2,3-triazole-4-amine (Ic-8) (150 mg) wasreacted with 2-(trifluoromethyl)benzoyl chloride (160 mg) andtriethylamine (0.21 ml) in 3.9 ml of dichloromethane. Purification bycolumn chromatography and preparative HPLC gave 143 mg of the titlecompound.

HPLC-MS: log P=2.80; mass (m/z): 369.1 (M+H)+; 1H-NMR (CD3CN) 7.45-7.49(m, 2H), 7.70-7.77 (m, 4H), 7.78-7.88 (m, 1H), 8.45 (s, 1H), 11.83 (s,1H).

SYNTHESIS EXAMPLE D Preparation ofN-[1-(3,5-difluoropyridin-2-yl)-1H-pyrazol-3-yl]-N-ethyl-2-(trifluoromethyl)benzamide(compound (I-1-468))

N-[1-(3,5-difluoropyridin-2-yl)-1H-pyrazol-3-yl]-2-(trifluoromethyl)benzamide(compound (I-1-140), 1 equiv) was placed in dry THF. NaH (1.5 equiv) wasadded at 0° C. The reaction mixture was stirred for 30 minutes.Ethyliodide (1.5 equiv) was then added and the reaction mixture wasstirred overnight at room temperature. Another 1 equivalent (twice 0.5equivalents) of NaH and of ethyliodide were added. The reaction mixturewas stirred at 50° C. overnight. The reaction mixture was cooled down,quenched with water and extracted with ethylacetate. The gatheredorganic phases were dried and evaporated. The residue was purified andthis gave the title compound. HPLC-MS and 1H-NMR: see table below(Compound I-1-468).

SYNTHESIS EXAMPLE D-BISN-[1-(3-Cyanopyrazin-2-yl)-1H-pyrazol-3-yl]-2-(trifluoromethyl)benzamide(Compound (I-1-574))

Step 1: N-(1H-Pyrazol-3-yl)-2-(trifluoromethyl)benzamide

With exclusion of moisture, a solution of 3-aminopyrazole (43.9 g) andtriethylamine (52.4 g) in acetonitrile (400 ml) was stirred at 0° C. forone hour. A solution of 2-(trifluoromethyl)benzoyl chloride (109.1 g) inacetonitrile (50 ml) was then added dropwise such that the internaltemperature did not exceed 7° C. The reaction was allowed to warm toroom temperature overnight, diluted with 600 ml of water and extractedwith ethyl acetate. The combined organic phases were dried overmagnesium sulphate, filtered and concentrated. The residue obtained inthis manner was dissolved in isopropanol (500 ml) under reflux. Aftercooling to room temperature, the crystals that had separated out wereisolated (48.6 g). This was the title compound with one molar equivalentof isopropanol of crystallization. HPLC-MS: log P=1.33, mass (m/z):255.9 (M+H)⁺; (DMSO-D6) 1.03 (m, 6H), 3.77 (m, 1H), 4.33 (m, 1H), 6.60(m, 1H), 7.60-7.81 (m, 5H), 10.97 (s, 1H), 12.41 (m, 1H).

Step 2:N-[1-(3-Cyanopyrazin-2-yl)-1H-pyrazol-3-yl]-2-(trifluoromethyl)benzamide(Compound (I-1-574))

The title compound was obtained starting with3-chloropyrazine-2-carbonitrile andN-(1H-pyrazol-3-yl)-2-(trifluoromethyl)benzamide using potassiumcarbonate as a base. HPLC-MS: log P=2.47; mass (m/z): 359.0 (M+H)⁺;1H-NMR (DMSO-D6) 7.12 (m, 1H), 7.72 (m, 2H), 7.78 (m, 1H), 7.83 (m, 1H),8.63 (m, 1H), 8.75 (m, 1H), 8.85 (m, 1H), 11.71 (s, 1H).

HPLC-MS1) and 1H-NMR data 2)

Compound No. HPLC-MS1) and 1H-NMR data2) I-1-75 see synthesis Example AI-1-83 HPLC-MS: logP = 2.67; mass (m/z): 426.1 (M + H)+; 1H-NMR [CD3CN]7.01 (d, 1H), 7.16-7.23 (m, 3H), 7.46-7.54 (m, 3H), 7.76 (d, 1H),7.93-7.95 (m, 1H), 9.15 (br. s, 1H). I-1-140 see synthesis Example BI-1-468: HPLC-MS: logP = 3.23; mass (m/z): 397.1 (M + H)+; 1H-NMR(400.0MHz, DMSO-D6): δ = 8.501(1.2); 8.415(4.9); 8.410(5.1); 8.383(1.3);8.317(0.5); 8.291(0.4); 8.270(0.7); 8.244(0.5); 8.219(1.5); 8.213(1.5);8.192(2.8); 8.171(2.1); 8.166(2.1); 8.151(5.2); 8.145(5.4); 8.078(1.5);8.073(1.7); 7.895(1.2); 7.870(1.9); 7.864(2.0); 7.832(1.1); 7.819(1.2);7.794(0.5); 7.767(1.3); 7.741(2.9); 7.717(4.5); 7.702 (3.4); 7.696(3.2);7.554(2.4); 7.535(6.5); 7.527(6.4); 7.518(5.1); 7.343(3.4); 7.335(3.5);7.322(2.6); 7.047(1.3);6.933(0.6); 6.060(5.2); 6.054(5.4); 5.757(0.7);5.722(1.6); 5.717(1.7); 4.206(0.6); 4.189(0.6); 4.128(0.8); 4.111(2.0);4.094(2.1); 4.077(0.7); 3.937(3.2); 3.833(0.7); 3.480(0.5);3.322(131.8); 2.675(2.4); 2.671(3.2); 2.667(2.5); 2.506(379.2);2.502(482.3); 2.497(374.3); 2.333(2.4); 2.328(3.2); 2.324(2.5);1.352(0.7); 1.336(1.2); 1.319(0.7); 1.260(2.2); 1.243(4.7); 1.227(9.5);1.210(16.0); 1.192(7.9); 1.122(3.3); 1.107(2.6); 0.146(1.3);0.000(278.2); −0.150(1.4) I-1-491: HPLC-MS: logP = 2.57; mass (m/z):387.1 (M + H)+; 1H-NMR(400.0 MHz, DMSO-D6): δ = 11.702(10.0);8.486(9.8); 8.480(10.4); 8.376(9.7); 8.369(9.8); 8.285(2.7); 8.279(2.5);8.264(2.9); 8.258 (5.1); 8.251(2.7); 8.237(2.7); 8.230(2.5); 7.778(0.8);7.757(2.6); 7.748(1.5); 7.738(5.3); 7.722(8.2); 7.701(16.0); 7.684(4.6);7.679(3.9); 6.981(12.1); 6.974(12.0); 3.518(1.0); 3.343(97.1);3.002(0.4); 2.716 (0.5); 2.571(0.3); 2.563(0.7); 2.546(116.6);2.530(0.6); 2.525(0.9); 2.516(12.3); 2.512(25.3); 2.507(34.0);2.502(25.0); 2.498(12.2); 2.372(0.5); 0.000(1.4) I-2-35 see synthesisExample C I-2-66: HPLC-MS: logP = 2.43; mass (m/z): 370.0 (M + H)+;1H-NMR(400.0 MHz, DMSO-D6): δ = 11.900(6.8); 11.873(0.6); 8.770(0.9);8.638(0.6); 8.632(0.7); 8.582(6.3); 8.576(6.6); 8.511(0.5); 8.462(16.0); 8.436(0.3); 8.404(2.2); 8.397(2.1); 8.389(0.4); 8.383(2.3);8.377(3.5); 8.372(2.1); 8.357(2.2); 8.351(2.0); 7.882(3.5); 7.862(4.4);7.827(1.1); 7.808(3.1); 7.792(3.9); 7.772(5.7); 7.761(3.6); 7.757(4.0);7.742(3.3); 7.724(1.2); 5.756(7.4); 3.324(31.3); 2.676(0.5); 2.672(0.6);2.667(0.4); 2.525(2.1); 2.520(3.2); 2.512(34.8); 2.507(69.2);2.503(90.5); 2.498(64.6); 2.494(30.5); 2.334(0.4); 2.330(0.6);2.325(0.4); 1.989(1.2); 1.352(0.7); 1.337(3.0); 1.299(1.1); 1.259(1.6);1.250(3.5); 1.234(1.0); 1.193(0.4); 1.175(0.7); 1.158(0.4); 0.008(2.2);0.000(63.5); −0.009(2.1) I-2-71: HPLC-MS: logP = 2.51; mass (m/z): 388.0(M + H)+; 1H-NMR(400.0 MHz, DMSO-D6): δ = 12.166(6.6); 8.587(6.2);8.580(6.6); 8.475(16.0); 8.408(2.2); 8.402(2.0); 8.387(2.3); 8.382(3.5);8.376(2.1); 8.362(2.2); 8.355(2.0); 7.832(0.5); 7.811(1.5); 7.802(0.9);7.792(3.1); 7.777(5.0); 7.754(8.2); 7.737 (2.3); 7.731(2.7); 5.758(4.8);3.330(26.6); 2.528(0.5); 2.515(11.2); 2.510(22.7); 2.506(29.8); 2.501(21.1); 2.497(9.8); 1.991(0.7); 1.397(0.8); 1.177(0.4); 0.000(1.8)

1) Description of Method for Determination of the log P Values (FormicAcid Method)

The log P values given in the table were determined in accordance withEEC Directive 79/831 Annex V.A8 by HPLC (High Performance LiquidChromatography) using a reversed-phase column (C 18). Temperature: 55°C.

Eluents for determination in the acidic range (pH 3.4):

Eluent A: acetonitrile+1 ml of formic acid/litre. Eluent B: water+0.9 mlof formic acid/litre.

Gradient: from 10% eluent A/90% eluent B to 95% eluent A/5% eluent B in4.25 min.

Calibration was carried out using unbranched alkan-2-ones (having from 3to 16 carbon atoms) with known log P values (the log P values weredetermined by the retention times using linear interpolation between twosuccessive alkanones). The lambda max values were determined in themaxima of the chromatographic signals using the UV spectra from 200 nmto 400 nm.

2) Measurement of the NMR Spectra of Selected Examples

The NMR spectra were determined using a Bruker Avance 400 fitted with aflow probe head (volume 60 μl). Solvents used were CD3CN or DMSO-D6, andtetramethylsilane (0.00 ppm) was used as reference. In individual cases,the NMR spectra were determined using a Bruker Avance II 600. Solventsused were CD3CN or DMSO-D6, and tetramethylsilane (0.00 ppm) was used asreference.

The NMR data for selected examples are listed either in conventionalform (d values, number of hydrogen atoms, multiplet splitting) or as NMRpeak lists.

The splitting of the signals was described as follows: s (singlet), d(doublet), t (triplet), q (quartet), quin (quintet), m (multiplet).

NMR peak list method

When the 1H NMR data for selected examples are noted in the form of 1HNMR peak lists, first the d value in ppm and then the signal intensityin round brackets are listed for each signal peak. The d value—signalintensity number pairs for different signal peaks are listed withseparation from one another by semicolons.

The peak list for one example therefore takes the form of:

δ1 (intensity1); δ2 (intensity2); . . . ; δi (intensityi); . . . ; δn(intensityn)

The intensity of sharp signals correlates with the height of the signalsin a printed example of an NMR spectrum in cm and shows the true ratiosof the signal intensities. In the case of broad signals, several peaksor the middle of the signal and their relative intensities may be shownin comparison to the most intense signal in the spectrum.

For calibration of the chemical shift of the 1H NMR spectra we usetetramethylsilane and/or the chemical shift of the solvent, particularlyin the case of spectra measured in DMSO. Therefore, thetetramethylsilane peak may but need not occur in the NMR peak lists.

The lists of the 1H NMR peaks are similar to the conventional 1H NMRprintouts and thus usually contain all peaks listed in conventional NMRinterpretations.

In addition, like conventional 1H NMR printouts, they may show solventsignals, signals of stereoisomers of the target compounds, whichlikewise form part of the subject-matter of the invention, and/or peaksof impurities.

In the reporting of compound signals in the delta range of solventsand/or water, our lists of 1H NMR peaks show the usual solvent peaks,for example peaks of DMSO in DMSO-d6 and the peak of water, whichusually have a high intensity on average.

The peaks of stereoisomers of the target compounds and/or peaks ofimpurities usually have a lower intensity on average than the peaks ofthe target compounds (for example with a purity of >90%).

Such stereoisomers and/or impurities may be typical of the particularpreparation process. Their peaks can thus help to identify reproductionof our preparation process with reference to “by-product fingerprints”.

An expert calculating the peaks of the target compounds by known methods(MestreC, ACD simulation, but also with empirically evaluated expectedvalues) can, if required, isolate the peaks of the target compounds,optionally using additional intensity filters. This isolation would besimilar to the relevant peak picking in conventional 1H NMRinterpretation.

Further details of 1H NMR peak lists can be found in Research DisclosureDatabase Number 564025.

The general concepts of the invention are described in the followingbiological examples, which are not to be considered as limiting.

BIOLOGICAL EXAMPLE E

Pratylenchus penetrans—Test (Soil Application)

Solvent: 4 parts by weight acetone

Emulsifier: 1 part by weight alkylaryl polyglycol ether

To produce a suitable preparation of active compound, 1 part by weightof active compound is mixed with solvent and emulsifier at the ratio 4:1and is diluted with water to the desired concentration.

This compound solution is mixed with 500 ml soil infected withPratylenchus penetrans (800 nematodes per 100 ml). The statedconcentration refers to the amount of compound per unit of volume soil(mg/1=ppm). The treated soil is filled into 500 ml pots and 3 corn seeds(Zea mays) are sown.

After 2 weeks the number of nematodes in the corn roots is determined bymeans of maceration. The roots are cleaned with water, cut into about 1cm pieces and minced with water in a mixer for 10-15 seconds. The piecesare poured over a 0.2 mm-nematode sieve, rinsed with 400 ml water andthe flow rate is collected. After 6 hours the supernatant is aspiratedand the number of nematodes is determined microscopically with acounting chamber.

The average number of nematodes per pot is determined and efficieny iscalculated by using Abbott's formula:

${{Efficiency}\mspace{14mu} \%} = {\left( {1 - \frac{{number}\mspace{14mu} {in}\mspace{14mu} T\mspace{14mu} {after}\mspace{14mu} {treatment}}{{number}\mspace{14mu} {in}\mspace{14mu} C}} \right) \times 100}$

T=treated plants

C=untreated control plants

In this test, for example, the following compounds from the preparationexamples showed good activity of 90% at an application rate of 2 ppm:I-2-35

In this test, for example, the following compounds from the preparationexamples showed good activity of 88% at an application rate of 2 ppm:I-1-75

In this test, for example, the following compounds from the preparationexamples showed good activity of 97% at an application rate of 4 ppm:I-1-574

BIOLOGICAL EXAMPLE F

Pratylenchus zeae—Test (PRATZE Soil Application)

Solvent: 4 parts by weight acetone

Emulsifier: 1 part by weight alkylaryl polyglycol ether

To produce a suitable preparation of active compound, 1 part by weightof active compound is mixed with solvent and emulsifier at the ratio 4:1and is diluted with water to the desired concentration.

This compound solution is mixed with 500 ml soil infected withPratylenchus zeae (800 nematodes per 100 ml). The stated concentrationrefers to the amount of compound per unit of volume soil (mg/1=ppm). Thetreated soil is filled into 500 ml pots and 3 corn seeds (Zea mays) aresown.

After 2 weeks the number of nematodes in the corn roots is determined bymeans of maceration. The roots are cleaned with water, cut into about 1cm pieces and minced with water in a mixer for 10-15 seconds. The piecesare poured over a 0.2 mm-nematode sieve, rinsed with 400 ml water andthe flow rate is collected. After 6 hours the supernatant is aspiratedand the number of nematodes is determined microscopically with acounting chamber.

The average number of nematodes per pot is determined and efficieny iscalculated by using Abbott's formula:

${{Efficiency}\mspace{14mu} \%} = {\left( {1 - \frac{{number}\mspace{14mu} {in}\mspace{14mu} T\mspace{14mu} {after}\mspace{14mu} {treatment}}{{number}\mspace{14mu} {in}\mspace{14mu} C}} \right) \times 100}$

T=treated plants

C=untreated control plants

In this test, for example, the following compounds from the preparationexamples showed good activity of 89% at an application rate of 2 ppm:I-1-75

BIOLOGICAL EXAMPLE G

Radopholus similis—Test (Soil Application)

Solvent: 4 parts by weight acetone

Emulsifier: 1 part by weight alkylaryl polyglycol ether

To produce a suitable preparation of active compound, 1 part by weightof active compound is mixed with solvent and emulsifier at the ratio 4:1and is diluted with water to the desired concentration.

This compound solution is mixed with soil. The stated concentrationrefers to the amount of compound per unit of volume soil (mg/1=ppm). Thetreated soil is filled into 250 ml pots and a banana seedling isplanted. Afterwards 2.5 ml of a nematode suspension (500 Radopholussimilis/ml) are applied.

After 2 weeks the number of nematodes in the banana roots is determinedby means of maceration. The roots are cut off, cleaned with water andafter adding 25-40 ml 0.01% lactic acid—acid fuchsin solution they areboiled in a microwave. On the next day the roots are rinsed over a 0.025mm-nematode sieve, roughly minced and macerated with 15-20 ml water inan Ultra Turrax. After filling up with water to 45 ml, the number ofnematodes in the supernatant is determined microscopically with acounting chamber.

The average number of nematodes per pot is determined and efficieny iscalculated by using Abbott's formula:

${{Efficiency}\mspace{14mu} \%} = {\left( {1 - \frac{{number}\mspace{14mu} {in}\mspace{14mu} T\mspace{14mu} {after}\mspace{14mu} {treatment}}{{number}\mspace{14mu} {in}\mspace{14mu} C}} \right) \times 100}$

T=treated plants

C=untreated control plants

In this test, for example, the following compounds from the preparationexamples showed good activity of 100% at an application rate of 2 ppm:I-1-140

In this test, for example, the following compounds from the preparationexamples showed good activity of 90% at an application rate of 2 ppm:I-1-75

In this test, for example, the following compounds from the preparationexamples showed good activity of 89% at an application rate of 2 ppm:I-1-491

In this test, for example, the following compounds from the preparationexamples showed good activity of 88% at an application rate of 2 ppm:I-1-83

BIOLOGICAL EXAMPLE H

Globodera rostochiensis—Test (Soil Application)

Solvent: 4 parts by weight acetone

Emulsifier: 1 part by weight alkylaryl polyglycol ether

To produce a suitable preparation of active compound, 1 part by weightof active compound is mixed with solvent and emulsifier at the ratio 4:1and is diluted with water to the desired concentration. This compoundcomposition is mixed with soil. The stated concentration refers to theamount of compound per unit of volume soil (mg/1=ppm).

450 ml of this compound composition is mixed with 50 ml of soil infectedwith Globodera rostochiensis (20.000 nematodes/100 ml), filled in 500 mlpots and a potato seedling is planted.

After six weeks the average number of cysts in the potato roots per potare determined and efficieny is calculated by using Abbott's formula:

${{Efficiency}\mspace{14mu} \%} = {\left( {1 - \frac{{number}\mspace{14mu} {in}\mspace{14mu} T\mspace{14mu} {after}\mspace{14mu} {treatment}}{{number}\mspace{14mu} {in}\mspace{14mu} C}} \right) \times 100}$

T=treated plants

C=untreated control plants

In this test, for example, the following compounds from the preparationexamples showed good activity of 100% at an application rate of 2 ppm:I-1-75, I-1-140, I-1-468, I-1-491, I-2-35, I-2-71

In this test, for example, the following compounds from the preparationexamples showed good activity of 98% at an application rate of 2 ppm:I-2-66

In this test, for example, the following compounds from the preparationexamples showed good activity of 80% at an application rate of 2 ppm:I-1-574

BIOLOGICAL EXAMPLE I

Meloidogyne incognita in Tomato—Test (MELGIN Soil Application)

Solvent: 4 parts by weight acetone

Emulsifier: 1 part by weight alkylaryl polyglycol ether

To produce a suitable preparation of active compound, 1 part by weightof active compound is mixed with solvent and emulsifier at the ratio 4:1and is diluted with water to the desired concentration. The statedconcentration refers to the amount of compound per unit of volume soil(mg/1=ppm).

This compound composition is mixed with 500 ml of soil and 4 ml of anematode suspension (1000 differenciated eggs and larvae of Meloidogyneincognita/ml). The stated concentration refers to the amount of compoundper unit of volume soil (mg/1=ppm). The treated soil is filled in 500 mlpots and a tomato seedling (Solanum lycopersicum) is planted.

After five weeks the average number of galls in the tomato roots per potare determined and efficieny is calculated by using Abbott's formula:

${{Efficiency}\mspace{14mu} \%} = {\left( {1 - \frac{{number}\mspace{14mu} {in}\mspace{14mu} T\mspace{14mu} {after}\mspace{14mu} {treatment}}{{number}\mspace{14mu} {in}\mspace{14mu} C}} \right) \times 100}$

T=treated plants

C=untreated control plants

In this test, for example, the following compounds from the preparationexamples showed good activity of 100% at an application rate of 2 ppm:I-1-75, I-1-140, I-2-66, I-2-35

1. A compound of formula (I)

in which A is A-1 or A-2 or A-3 in which the dotted line represents thebond to the N atom of Q, Q is Q-1 or Q-2 in which the nitrogen isattached to ring A and the arrow in each case represents the bond to theNRCO moiety, R is H or ethyl and W represents a radical from the groupconsisting of W-1 to W-3

in which the dotted line represents the bond to the C═O group, forcontrolling nematodes infesting one or more crops.
 2. The compound offormula (I) according to claim 1 wherein the crops are vegetables. 3.The compound of formula (I) according to claim 1 wherein the crops arefruits.
 4. The compound of formula (I) according to claim 1 wherein thecrops are grapes.
 5. The compound of formula (I) according to claim 1wherein the crops are pome fruits.
 6. The compound of formula (I)according to claim 1 wherein the crops are stone fruits.
 7. The compoundof formula (I) according to claim 1 wherein the crops are nuts.
 8. Thecompound of formula (I) according to claim 1 wherein the crops areflowers.
 9. A method of controlling nematodes comprising applying acompound of formula (I) as described in claim 1 to a plant.
 10. A methodfor increasing yield, comprising applying a compound of formula (I) asdescribed in claim 1 to a plant.